This article highlights significant disparities in cancer incidence, mortality, and survival rates among different racial and ethnic groups in the United States, particularly in relation to socioeconomic status. Residents of poorer counties (those with a poverty rate of 20% or more) have higher death rates from cancer compared to those in more affluent counties (poverty rate <10%). The five-year survival rate for all cancers combined is 10 percentage points lower among those living in poorer census tracts. Despite efforts to reduce disparities, African American, American Indian/Alaskan Native, and Asian/Pacific Islander men and women still have lower survival rates compared to non-Hispanic Whites. The article also discusses the impact of socioeconomic factors such as poverty, education, and health insurance on cancer risk factors, screening, stage at diagnosis, and treatment. It emphasizes the need for interventions in primary prevention, early detection, treatment, and palliative care to address these disparities.This article highlights significant disparities in cancer incidence, mortality, and survival rates among different racial and ethnic groups in the United States, particularly in relation to socioeconomic status. Residents of poorer counties (those with a poverty rate of 20% or more) have higher death rates from cancer compared to those in more affluent counties (poverty rate <10%). The five-year survival rate for all cancers combined is 10 percentage points lower among those living in poorer census tracts. Despite efforts to reduce disparities, African American, American Indian/Alaskan Native, and Asian/Pacific Islander men and women still have lower survival rates compared to non-Hispanic Whites. The article also discusses the impact of socioeconomic factors such as poverty, education, and health insurance on cancer risk factors, screening, stage at diagnosis, and treatment. It emphasizes the need for interventions in primary prevention, early detection, treatment, and palliative care to address these disparities.