This study examines cancer incidence trends across successive social generations in the United States, focusing on the comparison between Generation X (born 1965-1980) and Baby Boomers (born 1946-1964). Using data from the Surveillance, Epidemiology, and End Results (SEER) program, researchers analyzed 3.8 million invasive cancer cases diagnosed between 1992 and 2018. They employed statistical models to estimate incidence rates per 100,000 person-years at age 60 for different cancer sites, sex, and race/ethnicity groups. The findings show that Generation X has experienced larger per-capita increases in the incidence of leading cancers compared to any prior generation born between 1908 and 1964. For women, significant increases were observed in thyroid, kidney, rectal, corpus uterine, colon, pancreatic, and non-Hodgkin lymphoma cancers, while lung and cervical cancer incidence decreased. For men, increases were noted in thyroid, kidney, rectal, colon, and prostate cancers, along with leukemia, while lung, liver, and gallbladder cancer incidence decreased. The study also highlights that cancer incidence in Generation X is higher than in Baby Boomers for most cancers, except for Asian or Pacific Islander men. These trends suggest that cancer incidence may remain high for decades if current patterns continue. The research underscores the importance of addressing lifestyle factors and health disparities to mitigate future cancer risks. The study's conclusions emphasize the need for continued efforts in cancer prevention and early detection to reduce the burden of cancer in the United States.This study examines cancer incidence trends across successive social generations in the United States, focusing on the comparison between Generation X (born 1965-1980) and Baby Boomers (born 1946-1964). Using data from the Surveillance, Epidemiology, and End Results (SEER) program, researchers analyzed 3.8 million invasive cancer cases diagnosed between 1992 and 2018. They employed statistical models to estimate incidence rates per 100,000 person-years at age 60 for different cancer sites, sex, and race/ethnicity groups. The findings show that Generation X has experienced larger per-capita increases in the incidence of leading cancers compared to any prior generation born between 1908 and 1964. For women, significant increases were observed in thyroid, kidney, rectal, corpus uterine, colon, pancreatic, and non-Hodgkin lymphoma cancers, while lung and cervical cancer incidence decreased. For men, increases were noted in thyroid, kidney, rectal, colon, and prostate cancers, along with leukemia, while lung, liver, and gallbladder cancer incidence decreased. The study also highlights that cancer incidence in Generation X is higher than in Baby Boomers for most cancers, except for Asian or Pacific Islander men. These trends suggest that cancer incidence may remain high for decades if current patterns continue. The research underscores the importance of addressing lifestyle factors and health disparities to mitigate future cancer risks. The study's conclusions emphasize the need for continued efforts in cancer prevention and early detection to reduce the burden of cancer in the United States.