This study presents cancer incidence rates in Egypt based on data from the National Cancer Registry Program (NCRP). Egypt was divided into three geographical regions: Lower, Middle, and Upper Egypt. Each region was represented by one governorate, and data were collected from medical records, national tertiary care institutions, health insurance organizations, and death records. Incidence rates were calculated at both regional and national levels, and projections up to 2050 were also made. Age-standardized incidence rates per 100,000 were 166.6 (both sexes), 175.9 (males), and 157.0 (females). The most common cancer sites were liver (23.8%), breast (15.4%), and bladder (6.9%) for both sexes. Among males, liver (33.6%) and bladder (10.7%) were most common, while among females, breast (32.0%) and liver (13.5%) were most common. By 2050, cancer incidence is projected to increase threefold compared to 2013. These data are the first national and regional cancer incidence rates for Egypt. The study highlights the increasing burden of liver cancer and breast cancer as the second most common. The results indicate that the pattern of cancer in Egypt is influenced by factors such as hepatitis C virus infection and urinary schistosomiasis. The study also shows that the incidence rates of cancer in Egypt are intermediate between those of more and less developed countries. The study concludes that these data are essential for understanding the cancer burden in Egypt and for developing preventive programs. The study also highlights the importance of a population-based cancer registry for accurate cancer incidence data. The study also notes that the data should be interpreted carefully due to the short initial phase of registration and the use of a mathematical model. The study also highlights the need for further research to understand the differences in cancer incidence between the three regions of Egypt.This study presents cancer incidence rates in Egypt based on data from the National Cancer Registry Program (NCRP). Egypt was divided into three geographical regions: Lower, Middle, and Upper Egypt. Each region was represented by one governorate, and data were collected from medical records, national tertiary care institutions, health insurance organizations, and death records. Incidence rates were calculated at both regional and national levels, and projections up to 2050 were also made. Age-standardized incidence rates per 100,000 were 166.6 (both sexes), 175.9 (males), and 157.0 (females). The most common cancer sites were liver (23.8%), breast (15.4%), and bladder (6.9%) for both sexes. Among males, liver (33.6%) and bladder (10.7%) were most common, while among females, breast (32.0%) and liver (13.5%) were most common. By 2050, cancer incidence is projected to increase threefold compared to 2013. These data are the first national and regional cancer incidence rates for Egypt. The study highlights the increasing burden of liver cancer and breast cancer as the second most common. The results indicate that the pattern of cancer in Egypt is influenced by factors such as hepatitis C virus infection and urinary schistosomiasis. The study also shows that the incidence rates of cancer in Egypt are intermediate between those of more and less developed countries. The study concludes that these data are essential for understanding the cancer burden in Egypt and for developing preventive programs. The study also highlights the importance of a population-based cancer registry for accurate cancer incidence data. The study also notes that the data should be interpreted carefully due to the short initial phase of registration and the use of a mathematical model. The study also highlights the need for further research to understand the differences in cancer incidence between the three regions of Egypt.