This study presents the first published cancer incidence rates at national and regional levels in Egypt, based on data from the National Cancer Registry Program (NCRP). Egypt was divided into three geographical strata: Lower, Middle, and Upper Egypt, with one governorate representing each region. Data were collected from medical records, national tertiary care institutions, health insurance organizations, and death records. Age-standardized incidence rates were calculated, with liver cancer being the most common (33.6% among males and 13.5% among females), followed by breast cancer (32.0% among females). By 2050, the study projects a threefold increase in incident cancer cases relative to 2013, primarily due to population growth and demographic changes. The findings highlight the serious burden of liver cancer and the need for preventive programs. The study also discusses the challenges and strengths of the NCRP, emphasizing its role in providing accurate and sustainable cancer incidence data for Egypt.This study presents the first published cancer incidence rates at national and regional levels in Egypt, based on data from the National Cancer Registry Program (NCRP). Egypt was divided into three geographical strata: Lower, Middle, and Upper Egypt, with one governorate representing each region. Data were collected from medical records, national tertiary care institutions, health insurance organizations, and death records. Age-standardized incidence rates were calculated, with liver cancer being the most common (33.6% among males and 13.5% among females), followed by breast cancer (32.0% among females). By 2050, the study projects a threefold increase in incident cancer cases relative to 2013, primarily due to population growth and demographic changes. The findings highlight the serious burden of liver cancer and the need for preventive programs. The study also discusses the challenges and strengths of the NCRP, emphasizing its role in providing accurate and sustainable cancer incidence data for Egypt.