The twenty-seventh annual report of the Imperial Cancer Research Fund includes a review by Dr. W. Cramer on experimental carcinogenesis, which is proposed to be included in future reports. This review is seen as valuable for enhancing the quality of the publications, as critical evaluation is essential in medical research. While some criticize cancer research as unproductive, those with more knowledge recognize that progress requires persistent, multi-directional efforts. Over twenty-seven years, the Fund has accumulated substantial detailed knowledge about malignant processes, surpassing understanding of many common biological phenomena. Dr. J. A. Murray highlights observations from Dr. W. Cramer, who suggests that carcinoma development is not solely due to epithelial changes but also involves the removal of inhibitory factors from surrounding tissues. Dr. Ludford's findings on macrophages in tumour-bearing animals may relate to this process. Mr. Crabtree's research on cancer cell metabolism confirms Warburg's discovery that cancer cells produce lactic acid more than normal cells, indicating a unique metabolic activity that could aid in studying therapeutic effects. Dr. A. M. Begg's study of a filterable tumour in fowls shows a transformation from a low-malignancy to a more malignant and transmissible tumour. Dr. Begg and Dr. Cramer suggest that Rous sarcomas may arise from contamination of lab equipment with the virus, possibly due to experimental errors. Dr. Cramer's review of carcinogenesis provides new insights into cancer incidence and susceptibility, suggesting that cancer rates may be uniform across nations, though local factors may influence specific cancer types. This understanding helps explain variations in cancer organ incidence across countries.The twenty-seventh annual report of the Imperial Cancer Research Fund includes a review by Dr. W. Cramer on experimental carcinogenesis, which is proposed to be included in future reports. This review is seen as valuable for enhancing the quality of the publications, as critical evaluation is essential in medical research. While some criticize cancer research as unproductive, those with more knowledge recognize that progress requires persistent, multi-directional efforts. Over twenty-seven years, the Fund has accumulated substantial detailed knowledge about malignant processes, surpassing understanding of many common biological phenomena. Dr. J. A. Murray highlights observations from Dr. W. Cramer, who suggests that carcinoma development is not solely due to epithelial changes but also involves the removal of inhibitory factors from surrounding tissues. Dr. Ludford's findings on macrophages in tumour-bearing animals may relate to this process. Mr. Crabtree's research on cancer cell metabolism confirms Warburg's discovery that cancer cells produce lactic acid more than normal cells, indicating a unique metabolic activity that could aid in studying therapeutic effects. Dr. A. M. Begg's study of a filterable tumour in fowls shows a transformation from a low-malignancy to a more malignant and transmissible tumour. Dr. Begg and Dr. Cramer suggest that Rous sarcomas may arise from contamination of lab equipment with the virus, possibly due to experimental errors. Dr. Cramer's review of carcinogenesis provides new insights into cancer incidence and susceptibility, suggesting that cancer rates may be uniform across nations, though local factors may influence specific cancer types. This understanding helps explain variations in cancer organ incidence across countries.