The American Cancer Society's 2001 estimates indicate that approximately 1,268,000 new cases of cancer and 553,400 deaths from cancer are expected in the US. Overall cancer incidence and mortality rates have decreased since the early 1990s, with a more significant decline in recent years. Despite these reductions, the total number of recorded cancer deaths continues to increase due to an aging and expanding population. Racial and ethnic disparities persist, with Black men and women experiencing higher incidence rates and poorer survival compared to White men and women. The survival disparity reflects later stages of diagnosis and poorer outcomes within each stage. Prostate cancer incidence has shown marked fluctuations, influenced by PSA screening. The estimated numbers of new cancer cases and deaths are based on population data and age-specific incidence rates, with prostate cancer cases projected using historical data. Cancer remains a significant public health issue, and the society's estimates provide insights into current patterns to guide future efforts to reduce its burden.The American Cancer Society's 2001 estimates indicate that approximately 1,268,000 new cases of cancer and 553,400 deaths from cancer are expected in the US. Overall cancer incidence and mortality rates have decreased since the early 1990s, with a more significant decline in recent years. Despite these reductions, the total number of recorded cancer deaths continues to increase due to an aging and expanding population. Racial and ethnic disparities persist, with Black men and women experiencing higher incidence rates and poorer survival compared to White men and women. The survival disparity reflects later stages of diagnosis and poorer outcomes within each stage. Prostate cancer incidence has shown marked fluctuations, influenced by PSA screening. The estimated numbers of new cancer cases and deaths are based on population data and age-specific incidence rates, with prostate cancer cases projected using historical data. Cancer remains a significant public health issue, and the society's estimates provide insights into current patterns to guide future efforts to reduce its burden.