The 2001 Cancer Statistics report by the American Cancer Society estimates that 1,268,000 new cancer cases will be diagnosed in the US, with 553,400 deaths expected from cancer. Overall cancer incidence and mortality rates have decreased since the early 1990s, but the total number of cancer deaths continues to rise due to an aging population. Disparities in cancer incidence and mortality persist, with Black men and women experiencing higher rates and poorer survival compared to white individuals. Survival differences are attributed to later-stage diagnoses and poorer outcomes at each stage. The most common cancers in 2001 are prostate, lung and bronchus, and colon and rectum for men, and breast, lung and bronchus, and colon and rectum for women. Prostate cancer incidence has stabilized, while lung and bronchus cancer rates have declined. Cancer death rates have decreased overall, with significant declines among males and females under 75. However, death rates for lung and bronchus cancer have declined only among males, and female rates have started to slow. Cancer is the second leading cause of death among children aged 1–14 in the US, with leukemia being the most common cancer. Survival rates for childhood cancers have improved significantly over the past 25 years. Despite these improvements, cancer remains a major public health issue, with disparities in incidence and mortality across racial and ethnic groups. The report highlights the need for continued efforts to reduce the public health burden of cancer. Limitations include the use of outdated data and the potential for variability in estimates, particularly for less common cancers and smaller populations. The report provides a comprehensive overview of cancer trends and survival rates, emphasizing the importance of ongoing research and public health initiatives.The 2001 Cancer Statistics report by the American Cancer Society estimates that 1,268,000 new cancer cases will be diagnosed in the US, with 553,400 deaths expected from cancer. Overall cancer incidence and mortality rates have decreased since the early 1990s, but the total number of cancer deaths continues to rise due to an aging population. Disparities in cancer incidence and mortality persist, with Black men and women experiencing higher rates and poorer survival compared to white individuals. Survival differences are attributed to later-stage diagnoses and poorer outcomes at each stage. The most common cancers in 2001 are prostate, lung and bronchus, and colon and rectum for men, and breast, lung and bronchus, and colon and rectum for women. Prostate cancer incidence has stabilized, while lung and bronchus cancer rates have declined. Cancer death rates have decreased overall, with significant declines among males and females under 75. However, death rates for lung and bronchus cancer have declined only among males, and female rates have started to slow. Cancer is the second leading cause of death among children aged 1–14 in the US, with leukemia being the most common cancer. Survival rates for childhood cancers have improved significantly over the past 25 years. Despite these improvements, cancer remains a major public health issue, with disparities in incidence and mortality across racial and ethnic groups. The report highlights the need for continued efforts to reduce the public health burden of cancer. Limitations include the use of outdated data and the potential for variability in estimates, particularly for less common cancers and smaller populations. The report provides a comprehensive overview of cancer trends and survival rates, emphasizing the importance of ongoing research and public health initiatives.