The American Cancer Society (ACS) estimates that in 2007, there will be 1,444,920 new cancer cases and 559,650 deaths from cancer in the United States. The report examines incidence and mortality data through 2003 and 2004, respectively, and standardizes rates to the 2000 US population. Key trends include stabilization of incidence rates for all cancers combined in men from 1995 to 2003, a continuing increase in incidence rates by 0.3% per year in women, and a 13.6% decrease in age-standardized cancer death rates between 1991 and 2004. The report also provides detailed statistics on cancer incidence, mortality, and survival by site, sex, race/ethnicity, geographic area, and calendar year. While cancer deaths decreased for the second consecutive year, it still accounts for more deaths than heart disease in those under 85 years old. The report highlights the need for continued efforts to reduce the public health burden of cancer through new discoveries and the application of existing cancer control knowledge.The American Cancer Society (ACS) estimates that in 2007, there will be 1,444,920 new cancer cases and 559,650 deaths from cancer in the United States. The report examines incidence and mortality data through 2003 and 2004, respectively, and standardizes rates to the 2000 US population. Key trends include stabilization of incidence rates for all cancers combined in men from 1995 to 2003, a continuing increase in incidence rates by 0.3% per year in women, and a 13.6% decrease in age-standardized cancer death rates between 1991 and 2004. The report also provides detailed statistics on cancer incidence, mortality, and survival by site, sex, race/ethnicity, geographic area, and calendar year. While cancer deaths decreased for the second consecutive year, it still accounts for more deaths than heart disease in those under 85 years old. The report highlights the need for continued efforts to reduce the public health burden of cancer through new discoveries and the application of existing cancer control knowledge.