The American Cancer Society estimates that in 2010, there will be approximately 1,529,560 new cancer cases and 569,490 cancer deaths in the United States. Overall cancer incidence rates have decreased in both men (1.3% per year from 2000 to 2006) and women (0.5% per year from 1998 to 2006), primarily due to decreases in lung, prostate, colorectal, breast, and other cancers. Death rates from all cancers combined decreased by 21.0% in men and 12.3% in women between 1990 and 2006, with significant contributions from reductions in lung, prostate, colorectal, and breast cancers. These reductions have led to the avoidance of approximately 767,000 cancer deaths over a 16-year period. The report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, geographic area, and calendar year, highlighting progress in reducing incidence and mortality rates and improving survival. Despite these improvements, cancer remains a leading cause of death, particularly among those under 85 years old. Further progress can be achieved through the application of existing cancer control knowledge and support for new discoveries in prevention, early detection, and treatment.The American Cancer Society estimates that in 2010, there will be approximately 1,529,560 new cancer cases and 569,490 cancer deaths in the United States. Overall cancer incidence rates have decreased in both men (1.3% per year from 2000 to 2006) and women (0.5% per year from 1998 to 2006), primarily due to decreases in lung, prostate, colorectal, breast, and other cancers. Death rates from all cancers combined decreased by 21.0% in men and 12.3% in women between 1990 and 2006, with significant contributions from reductions in lung, prostate, colorectal, and breast cancers. These reductions have led to the avoidance of approximately 767,000 cancer deaths over a 16-year period. The report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, geographic area, and calendar year, highlighting progress in reducing incidence and mortality rates and improving survival. Despite these improvements, cancer remains a leading cause of death, particularly among those under 85 years old. Further progress can be achieved through the application of existing cancer control knowledge and support for new discoveries in prevention, early detection, and treatment.