The 2021 Cancer Statistics Report by the American Cancer Society provides an overview of cancer incidence and mortality in the United States. In 2021, an estimated 1,898,160 new cancer cases and 608,570 cancer deaths are projected to occur. The cancer death rate has declined continuously from its peak in 1991, reducing the number of cancer deaths by 3.2 million compared to if rates had remained at their peak. Prostate, lung, and colorectal cancers account for the majority of incident cases in men, while breast, lung, and colorectal cancers account for the majority in women. Lung cancer mortality has accelerated, driven by improvements in treatment and early detection, particularly for non-small cell lung cancer (NSCLC). Survival rates for NSCLC have improved, with a 2-year relative survival rate of 42% for those diagnosed in 2015-2016. Cancer incidence and mortality vary by race and ethnicity, with higher rates among non-Hispanic Black individuals compared to non-Hispanic White individuals. Geographic variations in cancer incidence and mortality reflect differences in detection practices and risk factor prevalence. Cancer is the second leading cause of death in children and adolescents, with leukemia and brain tumors being the most common types. Overall, cancer incidence in children and adolescents has increased slightly since 1975, while mortality rates have declined continuously.The 2021 Cancer Statistics Report by the American Cancer Society provides an overview of cancer incidence and mortality in the United States. In 2021, an estimated 1,898,160 new cancer cases and 608,570 cancer deaths are projected to occur. The cancer death rate has declined continuously from its peak in 1991, reducing the number of cancer deaths by 3.2 million compared to if rates had remained at their peak. Prostate, lung, and colorectal cancers account for the majority of incident cases in men, while breast, lung, and colorectal cancers account for the majority in women. Lung cancer mortality has accelerated, driven by improvements in treatment and early detection, particularly for non-small cell lung cancer (NSCLC). Survival rates for NSCLC have improved, with a 2-year relative survival rate of 42% for those diagnosed in 2015-2016. Cancer incidence and mortality vary by race and ethnicity, with higher rates among non-Hispanic Black individuals compared to non-Hispanic White individuals. Geographic variations in cancer incidence and mortality reflect differences in detection practices and risk factor prevalence. Cancer is the second leading cause of death in children and adolescents, with leukemia and brain tumors being the most common types. Overall, cancer incidence in children and adolescents has increased slightly since 1975, while mortality rates have declined continuously.