This study presents the 2014 nationwide cancer statistics in Korea, including incidence, survival, prevalence, and mortality. The data were obtained from the Korea National Cancer Incidence Database and Statistics Korea. In 2014, 217,057 new cancer cases and 76,611 cancer deaths were reported, with age-standardized incidence and mortality rates of 270.7 and 85.1 per 100,000, respectively. The all-cancer incidence rate increased by 3.4% annually from 1999 to 2012 but decreased by 6.6% from 2012 to 2014. Overall cancer mortality decreased by 2.7% annually since 2002. The 5-year relative survival rate improved from 41.2% in 1993-1995 to 70.3% in 2010-2014. Thyroid cancer was the most common among women, while stomach cancer was the most common among men. The cumulative risk of developing cancer from birth to life expectancy was 36.2%. The study highlights the need for continued efforts in cancer prevention and control to address the growing cancer burden in Korea.This study presents the 2014 nationwide cancer statistics in Korea, including incidence, survival, prevalence, and mortality. The data were obtained from the Korea National Cancer Incidence Database and Statistics Korea. In 2014, 217,057 new cancer cases and 76,611 cancer deaths were reported, with age-standardized incidence and mortality rates of 270.7 and 85.1 per 100,000, respectively. The all-cancer incidence rate increased by 3.4% annually from 1999 to 2012 but decreased by 6.6% from 2012 to 2014. Overall cancer mortality decreased by 2.7% annually since 2002. The 5-year relative survival rate improved from 41.2% in 1993-1995 to 70.3% in 2010-2014. Thyroid cancer was the most common among women, while stomach cancer was the most common among men. The cumulative risk of developing cancer from birth to life expectancy was 36.2%. The study highlights the need for continued efforts in cancer prevention and control to address the growing cancer burden in Korea.