The article reviews the role of dendritic cells (DCs) in cancer immunotherapy. DCs are crucial in coordinating the innate and adaptive immune responses, making them essential for generating therapeutic immunity against cancer. The authors discuss the complex interplay between the innate and adaptive immune systems, highlighting the importance of DCs in antigen presentation and immune regulation. They detail the biology of DCs, including their maturation, plasticity, and the diverse subsets found in the body. The article also explores how DCs can be targeted for therapeutic use, such as through ex vivo-generated vaccines and in vivo targeting of DCs with specific antibodies. The clinical efficacy of DC-based therapies is discussed, emphasizing the need for better understanding of immune responses and biomarkers to improve treatment outcomes. Finally, the authors reflect on the historical development of DC research and its potential future contributions to cancer immunotherapy.The article reviews the role of dendritic cells (DCs) in cancer immunotherapy. DCs are crucial in coordinating the innate and adaptive immune responses, making them essential for generating therapeutic immunity against cancer. The authors discuss the complex interplay between the innate and adaptive immune systems, highlighting the importance of DCs in antigen presentation and immune regulation. They detail the biology of DCs, including their maturation, plasticity, and the diverse subsets found in the body. The article also explores how DCs can be targeted for therapeutic use, such as through ex vivo-generated vaccines and in vivo targeting of DCs with specific antibodies. The clinical efficacy of DC-based therapies is discussed, emphasizing the need for better understanding of immune responses and biomarkers to improve treatment outcomes. Finally, the authors reflect on the historical development of DC research and its potential future contributions to cancer immunotherapy.