The study provides an updated estimate of cancer incidence and mortality in China for 2022, using data from 700 cancer registries and 106 registries with continuous monitoring from 2010 to 2018. The estimated number of new cancer cases in 2022 was 4,824,700, with lung, colon-rectum, thyroid, liver, and stomach cancers being the top five types, accounting for 57.42% of new cases. Lung, liver, stomach, colon-rectum, and esophageal cancers were the leading causes of cancer deaths, comprising 67.50% of total cancer deaths. The crude incidence and mortality rates were 341.75 and 182.34 per 100,000, respectively, while the age-standardized incidence and mortality rates (ASIR and ASMR) were 201.61 and 96.47 per 100,000. The ASIR of all cancers increased by about 1.4% annually from 2000 to 2018, while the ASMR decreased by about 1.3% annually. Trends in selected cancer sites showed varying patterns, with significant increases in thyroid and cervical cancers, and decreases in esophageal, stomach, and liver cancers. The study highlights the importance of continued efforts in cancer prevention, control, and early diagnosis to mitigate the increasing cancer burden in China.The study provides an updated estimate of cancer incidence and mortality in China for 2022, using data from 700 cancer registries and 106 registries with continuous monitoring from 2010 to 2018. The estimated number of new cancer cases in 2022 was 4,824,700, with lung, colon-rectum, thyroid, liver, and stomach cancers being the top five types, accounting for 57.42% of new cases. Lung, liver, stomach, colon-rectum, and esophageal cancers were the leading causes of cancer deaths, comprising 67.50% of total cancer deaths. The crude incidence and mortality rates were 341.75 and 182.34 per 100,000, respectively, while the age-standardized incidence and mortality rates (ASIR and ASMR) were 201.61 and 96.47 per 100,000. The ASIR of all cancers increased by about 1.4% annually from 2000 to 2018, while the ASMR decreased by about 1.3% annually. Trends in selected cancer sites showed varying patterns, with significant increases in thyroid and cervical cancers, and decreases in esophageal, stomach, and liver cancers. The study highlights the importance of continued efforts in cancer prevention, control, and early diagnosis to mitigate the increasing cancer burden in China.