This expert review highlights the preventability of cancer, emphasizing that only 5–10% of cancer cases are attributed to genetic defects, while 90–95% are influenced by environmental and lifestyle factors. Key lifestyle factors include smoking, diet (fatty and red meats), alcohol consumption, sun exposure, environmental pollutants, infections, stress, obesity, and physical inactivity. The review discusses the significant role of inflammation in linking these risk factors to cancer development and prevention. It provides evidence that cancer is preventable through major lifestyle changes, such as quitting smoking, increasing fruit and vegetable intake, moderate alcohol consumption, calorie restriction, regular exercise, avoiding direct sunlight, minimal meat consumption, using whole grains, and regular check-ups. The review also explores the chemopreventive potential of dietary agents, including phytochemicals from fruits, vegetables, spices, and grains, which can inhibit inflammation and reduce cancer risk.This expert review highlights the preventability of cancer, emphasizing that only 5–10% of cancer cases are attributed to genetic defects, while 90–95% are influenced by environmental and lifestyle factors. Key lifestyle factors include smoking, diet (fatty and red meats), alcohol consumption, sun exposure, environmental pollutants, infections, stress, obesity, and physical inactivity. The review discusses the significant role of inflammation in linking these risk factors to cancer development and prevention. It provides evidence that cancer is preventable through major lifestyle changes, such as quitting smoking, increasing fruit and vegetable intake, moderate alcohol consumption, calorie restriction, regular exercise, avoiding direct sunlight, minimal meat consumption, using whole grains, and regular check-ups. The review also explores the chemopreventive potential of dietary agents, including phytochemicals from fruits, vegetables, spices, and grains, which can inhibit inflammation and reduce cancer risk.