In 2013, the American Cancer Society estimated 1.66 million new cancer cases and 580,350 cancer deaths in the U.S. Cancer death rates have declined by 20% since their peak in 1991, with annual declines of 1.8% in men and 1.5% in women. The largest annual declines in death rates were for chronic myeloid leukemia (8.4%), stomach (3.1%), and colorectal (3.0%) cancers. These declines are attributed to improved early detection, treatment, and reduced tobacco use. Cancer death rates continue to decrease for the four major cancer sites: lung, colorectal, breast, and prostate. However, disparities persist among racial and ethnic groups, with African American men having higher cancer death rates than white men. Survival rates for cancer are lower among African Americans compared to whites, partly due to unequal access to quality healthcare. Cancer incidence rates have declined for most cancer sites, but rates for melanoma and liver and thyroid cancers have increased. The projected number of cancer cases and deaths in 2013 reflects the ongoing decline in cancer mortality, with about 1.18 million cancer deaths averted since the early 1990s. Regional variations in cancer rates exist, with lung cancer showing the largest geographic variation. Cancer is the second leading cause of death in the U.S., but it is the leading cause of death among individuals aged 40 to 79. In children, cancer is the second most common cause of death, with leukemia being the most common type. Overall, cancer statistics highlight the importance of continued efforts to reduce disparities and improve cancer control strategies.In 2013, the American Cancer Society estimated 1.66 million new cancer cases and 580,350 cancer deaths in the U.S. Cancer death rates have declined by 20% since their peak in 1991, with annual declines of 1.8% in men and 1.5% in women. The largest annual declines in death rates were for chronic myeloid leukemia (8.4%), stomach (3.1%), and colorectal (3.0%) cancers. These declines are attributed to improved early detection, treatment, and reduced tobacco use. Cancer death rates continue to decrease for the four major cancer sites: lung, colorectal, breast, and prostate. However, disparities persist among racial and ethnic groups, with African American men having higher cancer death rates than white men. Survival rates for cancer are lower among African Americans compared to whites, partly due to unequal access to quality healthcare. Cancer incidence rates have declined for most cancer sites, but rates for melanoma and liver and thyroid cancers have increased. The projected number of cancer cases and deaths in 2013 reflects the ongoing decline in cancer mortality, with about 1.18 million cancer deaths averted since the early 1990s. Regional variations in cancer rates exist, with lung cancer showing the largest geographic variation. Cancer is the second leading cause of death in the U.S., but it is the leading cause of death among individuals aged 40 to 79. In children, cancer is the second most common cause of death, with leukemia being the most common type. Overall, cancer statistics highlight the importance of continued efforts to reduce disparities and improve cancer control strategies.