The American Cancer Society estimates that in 2014, there will be 1,665,540 new cancer cases and 585,720 cancer deaths in the United States. Over the past five years (2006-2010), cancer incidence rates declined slightly in men (0.6% per year) and remained stable in women, while cancer death rates decreased by 1.8% per year in men and 1.4% per year in women. The combined cancer death rate has been continuously declining for two decades, from 215.1 per 100,000 population in 1991 to 171.8 in 2010, resulting in the avoidance of approximately 1,340,400 cancer deaths during this period. The decline in cancer death rates varies by age, race, and sex, with the largest declines observed among black men aged 40-49 years. The article also highlights the importance of applying existing cancer control knowledge to accelerate progress across all segments of the population.The American Cancer Society estimates that in 2014, there will be 1,665,540 new cancer cases and 585,720 cancer deaths in the United States. Over the past five years (2006-2010), cancer incidence rates declined slightly in men (0.6% per year) and remained stable in women, while cancer death rates decreased by 1.8% per year in men and 1.4% per year in women. The combined cancer death rate has been continuously declining for two decades, from 215.1 per 100,000 population in 1991 to 171.8 in 2010, resulting in the avoidance of approximately 1,340,400 cancer deaths during this period. The decline in cancer death rates varies by age, race, and sex, with the largest declines observed among black men aged 40-49 years. The article also highlights the importance of applying existing cancer control knowledge to accelerate progress across all segments of the population.