The American Cancer Society estimates that in 2015, there will be 1,658,370 new cancer cases and 589,430 cancer deaths in the United States. Incidence data were collected by the National Cancer Institute's SEER Program, the CDC's National Program of Cancer Registries, and the North American Association of Central Cancer Registries, while mortality data were collected by the National Center for Health Statistics. From 2007 to 2011, cancer incidence rates declined by 1.8% annually in men and remained stable in women, while cancer death rates decreased by 1.8% annually in men and 1.4% annually in women. Overall, the cancer death rate decreased from 215.1 per 100,000 population in 1991 to 168.7 in 2011, a 22% relative decline. However, this decline varied by state, with the Northeast having the highest decline (≥20%) and the South having the lowest (~15%). The article also presents trends in cancer incidence and survival rates, highlighting improvements in survival for most cancer types over the past three decades. Cancer incidence and death rates vary by race and ethnicity, with black men having the highest rates. Regional variations in cancer rates are significant, particularly for lung cancer, reflecting historical and ongoing differences in smoking prevalence. The article concludes that further reductions in cancer death rates can be achieved by applying existing cancer control knowledge across all segments of the population.The American Cancer Society estimates that in 2015, there will be 1,658,370 new cancer cases and 589,430 cancer deaths in the United States. Incidence data were collected by the National Cancer Institute's SEER Program, the CDC's National Program of Cancer Registries, and the North American Association of Central Cancer Registries, while mortality data were collected by the National Center for Health Statistics. From 2007 to 2011, cancer incidence rates declined by 1.8% annually in men and remained stable in women, while cancer death rates decreased by 1.8% annually in men and 1.4% annually in women. Overall, the cancer death rate decreased from 215.1 per 100,000 population in 1991 to 168.7 in 2011, a 22% relative decline. However, this decline varied by state, with the Northeast having the highest decline (≥20%) and the South having the lowest (~15%). The article also presents trends in cancer incidence and survival rates, highlighting improvements in survival for most cancer types over the past three decades. Cancer incidence and death rates vary by race and ethnicity, with black men having the highest rates. Regional variations in cancer rates are significant, particularly for lung cancer, reflecting historical and ongoing differences in smoking prevalence. The article concludes that further reductions in cancer death rates can be achieved by applying existing cancer control knowledge across all segments of the population.