The 2016 Cancer Statistics report estimates 1,685,210 new cancer cases and 595,690 cancer deaths in the United States. Overall cancer incidence trends are stable in women but declining by 3.1% per year in men, largely due to reduced prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, avoiding over 1.7 million deaths. However, death rates are increasing for liver, pancreas, and uterine cancers, and cancer is now the leading cause of death in 21 states. Brain cancer has surpassed leukemia as the leading cause of cancer death in children and adolescents. Cancer survival rates have improved significantly, with 5-year relative survival rates increasing by 20 percentage points for whites and 23 percentage points for blacks over 30 years. Despite progress, cancer remains a major public health issue, with lung and pancreatic cancers being the most deadly. Cancer incidence and death rates vary by race and ethnicity, with black men having higher rates than white men for most cancers. Regional variations in cancer rates are also significant, with lung cancer incidence rates differing widely by state. Cancer in children and adolescents has seen a 63% reduction in death rates over 40 years, with survival rates improving due to better treatment and clinical trials. The report highlights the need for continued research and application of cancer control knowledge to reduce the burden of cancer.The 2016 Cancer Statistics report estimates 1,685,210 new cancer cases and 595,690 cancer deaths in the United States. Overall cancer incidence trends are stable in women but declining by 3.1% per year in men, largely due to reduced prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, avoiding over 1.7 million deaths. However, death rates are increasing for liver, pancreas, and uterine cancers, and cancer is now the leading cause of death in 21 states. Brain cancer has surpassed leukemia as the leading cause of cancer death in children and adolescents. Cancer survival rates have improved significantly, with 5-year relative survival rates increasing by 20 percentage points for whites and 23 percentage points for blacks over 30 years. Despite progress, cancer remains a major public health issue, with lung and pancreatic cancers being the most deadly. Cancer incidence and death rates vary by race and ethnicity, with black men having higher rates than white men for most cancers. Regional variations in cancer rates are also significant, with lung cancer incidence rates differing widely by state. Cancer in children and adolescents has seen a 63% reduction in death rates over 40 years, with survival rates improving due to better treatment and clinical trials. The report highlights the need for continued research and application of cancer control knowledge to reduce the burden of cancer.