The 2016 Cancer Statistics report by the American Cancer Society provides an overview of cancer incidence, mortality, and survival rates in the United States. In 2016, it is projected that there will be 1,685,210 new cancer cases and 595,690 cancer deaths. Overall cancer incidence trends are stable in women but have declined by 3.1% per year in men, largely due to rapid declines in prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, saving over 1.7 million lives. However, death rates are increasing for cancers of the liver, pancreas, and uterine corpus. Cancer is now the leading cause of death in 21 states, primarily due to significant reductions in heart disease deaths. Among children and adolescents, brain cancer has surpassed leukemia as the leading cause of cancer death due to advancements in leukemia treatment. The report emphasizes the need for increased investment in cancer research and the application of existing cancer control knowledge to accelerate progress against cancer.The 2016 Cancer Statistics report by the American Cancer Society provides an overview of cancer incidence, mortality, and survival rates in the United States. In 2016, it is projected that there will be 1,685,210 new cancer cases and 595,690 cancer deaths. Overall cancer incidence trends are stable in women but have declined by 3.1% per year in men, largely due to rapid declines in prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, saving over 1.7 million lives. However, death rates are increasing for cancers of the liver, pancreas, and uterine corpus. Cancer is now the leading cause of death in 21 states, primarily due to significant reductions in heart disease deaths. Among children and adolescents, brain cancer has surpassed leukemia as the leading cause of cancer death due to advancements in leukemia treatment. The report emphasizes the need for increased investment in cancer research and the application of existing cancer control knowledge to accelerate progress against cancer.