The American Cancer Society estimates that in 2017, there will be 1,688,780 new cancer cases and 600,920 cancer deaths in the United States. The cancer incidence rate is 20% higher in men than in women, while the cancer death rate is 40% higher. Over the past decade, the overall cancer incidence rate in men declined by about 2% annually, while it remained stable in women. The cancer death rate declined by about 1.5% annually in both men and women. From 1991 to 2014, the overall cancer death rate dropped 25%, resulting in approximately 2,143,200 fewer cancer deaths than would have been expected if death rates had remained at their peak. Despite a 15% higher cancer death rate in blacks compared to whites in 2014, increasing access to care through the Affordable Care Act may narrow the racial gap. The article also discusses trends in cancer incidence and survival rates, regional variations, and disparities by sex and race/ethnicity.The American Cancer Society estimates that in 2017, there will be 1,688,780 new cancer cases and 600,920 cancer deaths in the United States. The cancer incidence rate is 20% higher in men than in women, while the cancer death rate is 40% higher. Over the past decade, the overall cancer incidence rate in men declined by about 2% annually, while it remained stable in women. The cancer death rate declined by about 1.5% annually in both men and women. From 1991 to 2014, the overall cancer death rate dropped 25%, resulting in approximately 2,143,200 fewer cancer deaths than would have been expected if death rates had remained at their peak. Despite a 15% higher cancer death rate in blacks compared to whites in 2014, increasing access to care through the Affordable Care Act may narrow the racial gap. The article also discusses trends in cancer incidence and survival rates, regional variations, and disparities by sex and race/ethnicity.