The 2018 American Cancer Society Cancer Statistics report estimates that 1,735,350 new cancer cases and 609,640 cancer deaths will occur in the United States. Over the past decade, cancer incidence rates remained stable in women and declined by about 2% annually in men, while cancer death rates declined by about 1.5% annually in both men and women. The combined cancer death rate dropped by 26% from 1991 to 2015, resulting in approximately 2.378 million fewer cancer deaths. Cancer was the only leading cause of death that declined from 2014 to 2015. Cancer death rates were 14% higher in non-Hispanic blacks (NHBs) than non-Hispanic whites (NHWs) overall, but the disparity was much larger for individuals aged <65 years. Racial disparities varied significantly by state, with some states showing lower rates in NHBs compared to NHWs. Cancer incidence and mortality data were compiled from multiple sources, including the Surveillance, Epidemiology, and End Results (SEER) Program, the National Program of Cancer Registries, and the North American Association of Central Cancer Registries. The report highlights trends in cancer incidence and mortality, noting declines in lung, colorectal, and prostate cancer rates, and increases in liver and melanoma rates. Survival rates for cancer have improved significantly, with 5-year relative survival rates for all cancers combined at 68% for whites and 61% for blacks. However, survival varies by cancer type and age at diagnosis. Cancer disparities by race/ethnicity remain significant, with NHBs having higher cancer mortality rates than NHWs. Geographic variation in cancer occurrence is also notable, with lung cancer incidence rates varying widely by state. The report emphasizes the importance of addressing socioeconomic and health policy factors to reduce cancer disparities. It also highlights the need for increased cancer prevention and early detection efforts, particularly in disadvantaged populations. The report concludes that while cancer death rates have declined significantly over the past two decades, persistent racial and geographic disparities remain, and further progress is needed to reduce the cancer burden in the United States.The 2018 American Cancer Society Cancer Statistics report estimates that 1,735,350 new cancer cases and 609,640 cancer deaths will occur in the United States. Over the past decade, cancer incidence rates remained stable in women and declined by about 2% annually in men, while cancer death rates declined by about 1.5% annually in both men and women. The combined cancer death rate dropped by 26% from 1991 to 2015, resulting in approximately 2.378 million fewer cancer deaths. Cancer was the only leading cause of death that declined from 2014 to 2015. Cancer death rates were 14% higher in non-Hispanic blacks (NHBs) than non-Hispanic whites (NHWs) overall, but the disparity was much larger for individuals aged <65 years. Racial disparities varied significantly by state, with some states showing lower rates in NHBs compared to NHWs. Cancer incidence and mortality data were compiled from multiple sources, including the Surveillance, Epidemiology, and End Results (SEER) Program, the National Program of Cancer Registries, and the North American Association of Central Cancer Registries. The report highlights trends in cancer incidence and mortality, noting declines in lung, colorectal, and prostate cancer rates, and increases in liver and melanoma rates. Survival rates for cancer have improved significantly, with 5-year relative survival rates for all cancers combined at 68% for whites and 61% for blacks. However, survival varies by cancer type and age at diagnosis. Cancer disparities by race/ethnicity remain significant, with NHBs having higher cancer mortality rates than NHWs. Geographic variation in cancer occurrence is also notable, with lung cancer incidence rates varying widely by state. The report emphasizes the importance of addressing socioeconomic and health policy factors to reduce cancer disparities. It also highlights the need for increased cancer prevention and early detection efforts, particularly in disadvantaged populations. The report concludes that while cancer death rates have declined significantly over the past two decades, persistent racial and geographic disparities remain, and further progress is needed to reduce the cancer burden in the United States.