The 2019 Cancer Statistics Report by the American Cancer Society provides an overview of cancer incidence, mortality, and survival rates in the United States. In 2019, an estimated 1,762,450 new cancer cases and 606,880 cancer deaths are projected to occur. Over the past decade, cancer incidence rates have remained stable in women and declined by about 2% annually in men, while cancer death rates have decreased by 1.4% and 1.8% annually for men and women, respectively. The overall cancer death rate has dropped by 27% from 1991 to 2016, resulting in approximately 2,629,200 fewer cancer deaths. Racial disparities in cancer mortality are narrowing, but socioeconomic inequalities are widening, with residents of poorer counties experiencing higher mortality rates for preventable cancers. The report also highlights the importance of addressing these disparities through increased access to healthcare and interventions for smoking cessation, healthy living, and cancer screening programs.The 2019 Cancer Statistics Report by the American Cancer Society provides an overview of cancer incidence, mortality, and survival rates in the United States. In 2019, an estimated 1,762,450 new cancer cases and 606,880 cancer deaths are projected to occur. Over the past decade, cancer incidence rates have remained stable in women and declined by about 2% annually in men, while cancer death rates have decreased by 1.4% and 1.8% annually for men and women, respectively. The overall cancer death rate has dropped by 27% from 1991 to 2016, resulting in approximately 2,629,200 fewer cancer deaths. Racial disparities in cancer mortality are narrowing, but socioeconomic inequalities are widening, with residents of poorer counties experiencing higher mortality rates for preventable cancers. The report also highlights the importance of addressing these disparities through increased access to healthcare and interventions for smoking cessation, healthy living, and cancer screening programs.