The American Cancer Society's 2020 report on cancer statistics estimates that 1,806,590 new cancer cases and 606,520 cancer deaths will occur in the United States in 2020. The cancer death rate has declined continuously since 1991, resulting in an overall decline of 2% and an estimated 2.9 million fewer cancer deaths. This progress is driven by long-term declines in death rates for the four leading cancers (lung, colorectal, breast, and prostate). However, recent trends show slowing reductions for female breast and colorectal cancers, and a halt in the decline for prostate cancer. Lung cancer remains the leading cause of cancer deaths, surpassing breast, prostate, and colorectal cancers combined. Melanoma of the skin has seen dramatic mortality declines due to new therapies, with annual declines of 7% from 2013 to 2017. Liver cancer mortality has also slowed in women and stabilized in men. The report highlights racial and geographic disparities, with higher incidence and mortality rates among non-Hispanic whites and certain states. Cancer survival rates have improved for most common cancers, but disparities persist, particularly for black patients. The report emphasizes the need for continued investment in cancer control interventions and research to accelerate progress against cancer.The American Cancer Society's 2020 report on cancer statistics estimates that 1,806,590 new cancer cases and 606,520 cancer deaths will occur in the United States in 2020. The cancer death rate has declined continuously since 1991, resulting in an overall decline of 2% and an estimated 2.9 million fewer cancer deaths. This progress is driven by long-term declines in death rates for the four leading cancers (lung, colorectal, breast, and prostate). However, recent trends show slowing reductions for female breast and colorectal cancers, and a halt in the decline for prostate cancer. Lung cancer remains the leading cause of cancer deaths, surpassing breast, prostate, and colorectal cancers combined. Melanoma of the skin has seen dramatic mortality declines due to new therapies, with annual declines of 7% from 2013 to 2017. Liver cancer mortality has also slowed in women and stabilized in men. The report highlights racial and geographic disparities, with higher incidence and mortality rates among non-Hispanic whites and certain states. Cancer survival rates have improved for most common cancers, but disparities persist, particularly for black patients. The report emphasizes the need for continued investment in cancer control interventions and research to accelerate progress against cancer.