The American Cancer Society estimates that in 2023, there will be approximately 1,958,310 new cancer cases and 609,820 cancer deaths in the United States. Prostate cancer incidence increased by 3% annually from 2014 to 2019, while other cancers showed more favorable trends in men compared to women. Lung cancer incidence in women decreased at half the rate of men from 2015 to 2019, and breast, uterine corpus, liver, and melanoma cancers continued to increase. Cervical cancer incidence dropped by 65% among women in their early 20s, the first cohort to receive the human papillomavirus (HPV) vaccine. Despite the pandemic, cancer death rates continued to decline from 2019 to 2020, contributing to a 33% overall reduction since 1991. Treatment advances have led to rapid declines in mortality for leukemia, melanoma, and kidney cancer, despite stable or increasing incidence. However, future progress may be hindered by rising incidence rates for breast, prostate, and uterine corpus cancers, which also have significant racial disparities in mortality. The article provides detailed data on cancer incidence and mortality by state and highlights the disproportionate impact of the pandemic on communities of color.The American Cancer Society estimates that in 2023, there will be approximately 1,958,310 new cancer cases and 609,820 cancer deaths in the United States. Prostate cancer incidence increased by 3% annually from 2014 to 2019, while other cancers showed more favorable trends in men compared to women. Lung cancer incidence in women decreased at half the rate of men from 2015 to 2019, and breast, uterine corpus, liver, and melanoma cancers continued to increase. Cervical cancer incidence dropped by 65% among women in their early 20s, the first cohort to receive the human papillomavirus (HPV) vaccine. Despite the pandemic, cancer death rates continued to decline from 2019 to 2020, contributing to a 33% overall reduction since 1991. Treatment advances have led to rapid declines in mortality for leukemia, melanoma, and kidney cancer, despite stable or increasing incidence. However, future progress may be hindered by rising incidence rates for breast, prostate, and uterine corpus cancers, which also have significant racial disparities in mortality. The article provides detailed data on cancer incidence and mortality by state and highlights the disproportionate impact of the pandemic on communities of color.