The American Cancer Society estimates that in 2024, there will be 2,001,140 new cancer cases and 611,720 cancer deaths in the United States. Cancer mortality has declined since 1991 due to reduced smoking, earlier detection, and improved treatments, but incidence rates for six of the top 10 cancers have increased. Incidence rates for breast, pancreas, and uterine corpus cancers increased by 0.6%–1% annually from 2015 to 2019, while rates for prostate, liver (female), kidney, and human papillomavirus-associated oral cancers increased by 2%–3% annually. Incidence rates also increased for cervical and colorectal cancers in young adults. Colorectal cancer is now the fourth-leading cause of cancer death in both men and women under 50 years old. Cancer disparities persist, with higher mortality rates for prostate, stomach, and uterine corpus cancers among Black people and for liver, stomach, and kidney cancers among Native American people. The continued national progress requires increased investment in cancer prevention and equitable access to treatment, especially for American Indian and Alaska Native and Black individuals.The American Cancer Society estimates that in 2024, there will be 2,001,140 new cancer cases and 611,720 cancer deaths in the United States. Cancer mortality has declined since 1991 due to reduced smoking, earlier detection, and improved treatments, but incidence rates for six of the top 10 cancers have increased. Incidence rates for breast, pancreas, and uterine corpus cancers increased by 0.6%–1% annually from 2015 to 2019, while rates for prostate, liver (female), kidney, and human papillomavirus-associated oral cancers increased by 2%–3% annually. Incidence rates also increased for cervical and colorectal cancers in young adults. Colorectal cancer is now the fourth-leading cause of cancer death in both men and women under 50 years old. Cancer disparities persist, with higher mortality rates for prostate, stomach, and uterine corpus cancers among Black people and for liver, stomach, and kidney cancers among Native American people. The continued national progress requires increased investment in cancer prevention and equitable access to treatment, especially for American Indian and Alaska Native and Black individuals.