This study compares cancer profiles, trends, and determinants in China and the United States for 2022. Using open-source data, the researchers estimated that China will have approximately 4,820,000 new cancer cases and 3,210,000 cancer deaths in 2022, while the USA will have 2,370,000 new cases and 640,000 deaths. Lung cancer is the most common in China and the leading cause of cancer death in both countries, while breast cancer is the most common in the USA. Trends show that incidence and mortality rates for cancers of the stomach, liver, and esophagus have decreased in both countries, but rates for colorectal, prostate, and other cancers have increased. Population aging is a major determinant of incremental cancer deaths, and case-fatality rates have contributed to reduced cancer deaths in both countries. The study suggests that China's cancer profile is converging with that of the USA, and that China can benefit from adopting some of the USA's effective prevention measures and actions to support healthy aging.This study compares cancer profiles, trends, and determinants in China and the United States for 2022. Using open-source data, the researchers estimated that China will have approximately 4,820,000 new cancer cases and 3,210,000 cancer deaths in 2022, while the USA will have 2,370,000 new cases and 640,000 deaths. Lung cancer is the most common in China and the leading cause of cancer death in both countries, while breast cancer is the most common in the USA. Trends show that incidence and mortality rates for cancers of the stomach, liver, and esophagus have decreased in both countries, but rates for colorectal, prostate, and other cancers have increased. Population aging is a major determinant of incremental cancer deaths, and case-fatality rates have contributed to reduced cancer deaths in both countries. The study suggests that China's cancer profile is converging with that of the USA, and that China can benefit from adopting some of the USA's effective prevention measures and actions to support healthy aging.