This study investigates the use of cerium ions (Ce3+) loaded into hydrogel microspheres to promote bone regeneration. The researchers developed a living and phosphorylated injectable porous hydrogel microsphere (P-GelMA-Ce@BMSGS) using microfluidic technology and coordination reactions with metal ion ligands. Exogenous stem cells can adhere to and proliferate on these microspheres, enhancing cell-extracellular matrix (ECM) interactions and cell-cell interactions. The activation of the Wnt/β-catenin pathway promotes the proliferation, osteogenic differentiation, and angiogenesis of endothelial cells by facilitating mineral deposition, osteogenic gene expression, and VEGF secretion. The study demonstrates that the P-GelMA-Ce scaffold enhances osteogenesis and angiogenesis, primarily through the activation of the Wnt/β-catenin pathway. This research provides novel insights into the treatment of bone defects using biofunctional materials based on metal ions.This study investigates the use of cerium ions (Ce3+) loaded into hydrogel microspheres to promote bone regeneration. The researchers developed a living and phosphorylated injectable porous hydrogel microsphere (P-GelMA-Ce@BMSGS) using microfluidic technology and coordination reactions with metal ion ligands. Exogenous stem cells can adhere to and proliferate on these microspheres, enhancing cell-extracellular matrix (ECM) interactions and cell-cell interactions. The activation of the Wnt/β-catenin pathway promotes the proliferation, osteogenic differentiation, and angiogenesis of endothelial cells by facilitating mineral deposition, osteogenic gene expression, and VEGF secretion. The study demonstrates that the P-GelMA-Ce scaffold enhances osteogenesis and angiogenesis, primarily through the activation of the Wnt/β-catenin pathway. This research provides novel insights into the treatment of bone defects using biofunctional materials based on metal ions.