The article discusses the epidemiology and prevention of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Over the past decade, the prevalence of CRE has increased due to the emergence of carbapenemase-producing strains, particularly Klebsiella pneumoniae carbapenemase (KPC). Other carbapenemase subtypes, such as New Delhi metallo-β-lactamase (NDM), have also been identified. These enzymes are often found on mobile genetic elements and can spread widely, making prevention of CRE transmission and infection a critical public health objective. The article highlights the high mortality rates associated with CRE infections and the limited treatment options available. It reviews the epidemiology of CRE, including the rise in carbapenem resistance among Enterobacteriaceae, the spread of KPC-producing strains, and the emergence of NDM. The risk factors for CRE acquisition, such as healthcare exposure and antimicrobial use, are discussed, along with the importance of early detection and surveillance cultures to identify and control CRE infections. Prevention strategies, including laboratory detection, antimicrobial stewardship, limiting device use, and public health interventions, are emphasized. The CDC's recommendations for preventing CRE transmission in acute care facilities are outlined, along with the need for broader prevention efforts in nonacute care settings and enhanced communication between healthcare providers. The article concludes by highlighting the importance of public health in coordinating prevention efforts and improving community situational awareness.The article discusses the epidemiology and prevention of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Over the past decade, the prevalence of CRE has increased due to the emergence of carbapenemase-producing strains, particularly Klebsiella pneumoniae carbapenemase (KPC). Other carbapenemase subtypes, such as New Delhi metallo-β-lactamase (NDM), have also been identified. These enzymes are often found on mobile genetic elements and can spread widely, making prevention of CRE transmission and infection a critical public health objective. The article highlights the high mortality rates associated with CRE infections and the limited treatment options available. It reviews the epidemiology of CRE, including the rise in carbapenem resistance among Enterobacteriaceae, the spread of KPC-producing strains, and the emergence of NDM. The risk factors for CRE acquisition, such as healthcare exposure and antimicrobial use, are discussed, along with the importance of early detection and surveillance cultures to identify and control CRE infections. Prevention strategies, including laboratory detection, antimicrobial stewardship, limiting device use, and public health interventions, are emphasized. The CDC's recommendations for preventing CRE transmission in acute care facilities are outlined, along with the need for broader prevention efforts in nonacute care settings and enhanced communication between healthcare providers. The article concludes by highlighting the importance of public health in coordinating prevention efforts and improving community situational awareness.