Carbonic anhydrase (CA) is a key enzyme involved in vascular function, and its inhibitors (CAIs) have been shown to affect blood flow and vascular tone. CA is present in various vascular cells and capillary subtypes, including endothelial cells and smooth muscle cells. CA inhibitors, such as sulfonamides, have been found to dilate vessels and increase blood flow in the cerebral and ocular vasculature. However, the exact mechanism by which CAIs exert their effects on the vasculature is still unclear. The study highlights that CA isoforms, such as CA II and CA IV, play a role in vascular function, and that the effects of CAIs on vascular tone may involve interactions with various transport proteins and signaling pathways. The study also discusses the role of CA in regulating blood flow, particularly in the brain and eye, and the potential therapeutic applications of CAIs in conditions such as glaucoma and vascular diseases. The findings suggest that CA inhibitors may have complex effects on vascular function, and that further research is needed to fully understand the mechanisms involved. The study emphasizes the importance of understanding the role of CA in vascular function and the potential of CAIs as therapeutic agents for vascular diseases.Carbonic anhydrase (CA) is a key enzyme involved in vascular function, and its inhibitors (CAIs) have been shown to affect blood flow and vascular tone. CA is present in various vascular cells and capillary subtypes, including endothelial cells and smooth muscle cells. CA inhibitors, such as sulfonamides, have been found to dilate vessels and increase blood flow in the cerebral and ocular vasculature. However, the exact mechanism by which CAIs exert their effects on the vasculature is still unclear. The study highlights that CA isoforms, such as CA II and CA IV, play a role in vascular function, and that the effects of CAIs on vascular tone may involve interactions with various transport proteins and signaling pathways. The study also discusses the role of CA in regulating blood flow, particularly in the brain and eye, and the potential therapeutic applications of CAIs in conditions such as glaucoma and vascular diseases. The findings suggest that CA inhibitors may have complex effects on vascular function, and that further research is needed to fully understand the mechanisms involved. The study emphasizes the importance of understanding the role of CA in vascular function and the potential of CAIs as therapeutic agents for vascular diseases.