This study investigates the cardiovascular mortality and medication use in patients with takotsubo syndrome compared to the general population and patients with acute myocardial infarction. Using data from Scotland between 2010 and 2017, the researchers found that patients with takotsubo syndrome had higher all-cause mortality compared to the general population, particularly due to cardiovascular and noncardiovascular deaths. Despite similar medication use, cardiovascular therapies were associated with better survival in patients with myocardial infarction but not in those with takotsubo syndrome. Diuretic, anti-inflammatory, and psychotropic therapies were associated with worse outcomes in patients with takotsubo syndrome. The study highlights the need for further research to understand the long-term effects of medications and to explore potential mechanisms and treatments for this condition.This study investigates the cardiovascular mortality and medication use in patients with takotsubo syndrome compared to the general population and patients with acute myocardial infarction. Using data from Scotland between 2010 and 2017, the researchers found that patients with takotsubo syndrome had higher all-cause mortality compared to the general population, particularly due to cardiovascular and noncardiovascular deaths. Despite similar medication use, cardiovascular therapies were associated with better survival in patients with myocardial infarction but not in those with takotsubo syndrome. Diuretic, anti-inflammatory, and psychotropic therapies were associated with worse outcomes in patients with takotsubo syndrome. The study highlights the need for further research to understand the long-term effects of medications and to explore potential mechanisms and treatments for this condition.