Pyroptosis is a form of programmed cell death characterized by rapid lysis of the affected cell, distinct from apoptosis and oncosis. It is triggered by Caspase-1, activated by various inflammasomes, and results in the release of cytosolic contents into the extracellular space. Unlike apoptosis, pyroptosis involves the processing of pro-Caspase-1 to mature Caspase-1, which then cleaves pro-IL-1β and pro-IL-18, leading to their secretion. The role of pyroptosis in vivo has been demonstrated in models of bacterial infection, where it plays a crucial role in clearing intracellular pathogens. Pyroptosis is initiated by different mechanisms in different inflammasomes, such as NLRC4, NLRP3, and AIM2, and can be regulated by the adaptor protein ASC. The formation of ASC foci is critical for cytokine processing and pyroptosis induction. Pyroptosis is a potent innate immune effector mechanism that contributes to the clearance of intracellular pathogens, and its function is essential in infectious and inflammatory diseases.Pyroptosis is a form of programmed cell death characterized by rapid lysis of the affected cell, distinct from apoptosis and oncosis. It is triggered by Caspase-1, activated by various inflammasomes, and results in the release of cytosolic contents into the extracellular space. Unlike apoptosis, pyroptosis involves the processing of pro-Caspase-1 to mature Caspase-1, which then cleaves pro-IL-1β and pro-IL-18, leading to their secretion. The role of pyroptosis in vivo has been demonstrated in models of bacterial infection, where it plays a crucial role in clearing intracellular pathogens. Pyroptosis is initiated by different mechanisms in different inflammasomes, such as NLRC4, NLRP3, and AIM2, and can be regulated by the adaptor protein ASC. The formation of ASC foci is critical for cytokine processing and pyroptosis induction. Pyroptosis is a potent innate immune effector mechanism that contributes to the clearance of intracellular pathogens, and its function is essential in infectious and inflammatory diseases.