The study investigates the use of catalase-powered nanobots to overcome the mucus barrier, a significant obstacle in drug delivery. The researchers synthesized mesoporous silica nanoparticles (MSNPs) and functionalized them with catalase and polyethylene glycol (PEG) to create nanobots. These nanobots were tested for their ability to disrupt mucus and self-propel, both individually and in swarms. The results showed that the nanobots effectively disrupted mucus, reducing its viscosity, and significantly increased the penetration rate through the mucus barrier compared to passive nanoparticles. In vitro and ex vivo studies confirmed the effectiveness of the nanobots in disrupting intestinal mucus, with a 60-fold increase in penetration compared to passive nanoparticles. The study highlights the potential of catalase-powered nanobots as promising drug carriers, particularly for conditions where the mucus barrier poses a significant challenge to efficient therapy delivery.The study investigates the use of catalase-powered nanobots to overcome the mucus barrier, a significant obstacle in drug delivery. The researchers synthesized mesoporous silica nanoparticles (MSNPs) and functionalized them with catalase and polyethylene glycol (PEG) to create nanobots. These nanobots were tested for their ability to disrupt mucus and self-propel, both individually and in swarms. The results showed that the nanobots effectively disrupted mucus, reducing its viscosity, and significantly increased the penetration rate through the mucus barrier compared to passive nanoparticles. In vitro and ex vivo studies confirmed the effectiveness of the nanobots in disrupting intestinal mucus, with a 60-fold increase in penetration compared to passive nanoparticles. The study highlights the potential of catalase-powered nanobots as promising drug carriers, particularly for conditions where the mucus barrier poses a significant challenge to efficient therapy delivery.