Felix Mitelman's "Catalog of Chromosome Aberrations in Cancer" (Fifth Edition) is a comprehensive reference book that documents chromosomal abnormalities in malignancies. The fifth edition, published by Wiley-Liss, Inc., in 1994, includes over 22,000 individual neoplasms from 5224 references, reflecting the rapid growth in research over the past decade. The catalog is divided into two volumes, covering chromosomes 1-12 and 13-22, XY, with cases classified by chromosome and disease type. Solid tumors, though still underrepresented, contribute significantly due to their complex karyotypes. The catalog uses the latest terminology from the International System for Cytogenetic Nomenclature 1991 and includes molecular data on genetic rearrangements and fusion genes. Entries are sourced from over 30 scientific journals worldwide, with Europe being the largest contributor. The catalog highlights clinically important chromosomal subgroups within morphologically identical malignant disorders, providing a valuable resource for researchers and clinicians. It is well-designed, user-friendly, and includes a comprehensive bibliography, making it an essential tool for anyone working on cytogenetic or molecular changes in malignancy.Felix Mitelman's "Catalog of Chromosome Aberrations in Cancer" (Fifth Edition) is a comprehensive reference book that documents chromosomal abnormalities in malignancies. The fifth edition, published by Wiley-Liss, Inc., in 1994, includes over 22,000 individual neoplasms from 5224 references, reflecting the rapid growth in research over the past decade. The catalog is divided into two volumes, covering chromosomes 1-12 and 13-22, XY, with cases classified by chromosome and disease type. Solid tumors, though still underrepresented, contribute significantly due to their complex karyotypes. The catalog uses the latest terminology from the International System for Cytogenetic Nomenclature 1991 and includes molecular data on genetic rearrangements and fusion genes. Entries are sourced from over 30 scientific journals worldwide, with Europe being the largest contributor. The catalog highlights clinically important chromosomal subgroups within morphologically identical malignant disorders, providing a valuable resource for researchers and clinicians. It is well-designed, user-friendly, and includes a comprehensive bibliography, making it an essential tool for anyone working on cytogenetic or molecular changes in malignancy.