2018 | Macarena Martínez-Cuitiño; Federico Soriano; Jesica Formoso; Geraldine Borovinsky; Jesica Ferrari; Noelia Pontello; Juan Pablo Barreiro; Facundo Manes
This study investigates the processing of concrete and abstract concepts in patients with Semantic Variant Primary Progressive Aphasia (sv-APP). The sv-APP is characterized by progressive damage to conceptual knowledge, with some studies reporting a higher impact on abstract concepts compared to concrete ones, known as the concreteness effect. However, other studies have found an inverse concreteness effect, where patients perform better with abstract concepts. The study compares the performance of 8 sv-APP patients and 20 matched healthy controls using a synonyms judgment task. The results show a concreteness effect, indicating better performance with concrete concepts, both for nouns and verbs. These findings align with previous research showing worse performance in sv-APP patients with abstract concepts. The observed effect supports the hypothesis of an anodal semantic hub that processes both types of concepts. The lower impact on concrete concepts could be explained by their greater semantic richness. The study also discusses the implications of these findings for understanding the neural basis of semantic processing in sv-APP.This study investigates the processing of concrete and abstract concepts in patients with Semantic Variant Primary Progressive Aphasia (sv-APP). The sv-APP is characterized by progressive damage to conceptual knowledge, with some studies reporting a higher impact on abstract concepts compared to concrete ones, known as the concreteness effect. However, other studies have found an inverse concreteness effect, where patients perform better with abstract concepts. The study compares the performance of 8 sv-APP patients and 20 matched healthy controls using a synonyms judgment task. The results show a concreteness effect, indicating better performance with concrete concepts, both for nouns and verbs. These findings align with previous research showing worse performance in sv-APP patients with abstract concepts. The observed effect supports the hypothesis of an anodal semantic hub that processes both types of concepts. The lower impact on concrete concepts could be explained by their greater semantic richness. The study also discusses the implications of these findings for understanding the neural basis of semantic processing in sv-APP.