Gonorrhea, a sexually transmitted infection caused by *Neisseria gonorrhoeae*, remains a significant public health concern in China. In 2022, China reported 96,313 cases of gonorrhea, making it the fourth most common notifiable infectious disease. The rise in antimicrobial-resistant strains, particularly ceftriaxone-resistant clones, poses a significant challenge to control efforts. The China Gonococcal Resistance Surveillance Program (China-GRSP) monitored 2,804 gonococcal isolates from 13 provinces, representing 4.1% of all reported cases. The prevalence of ceftriaxone resistance increased from 2.9% in 2017 to 8.1% in 2022, with five provinces reporting >10% resistance. Resistance to other antibiotics, such as ciprofloxacin (97.6%), penicillin (77.8%), tetracycline (77.1%), azithromycin (16.9%), and cefixime (16.0%), was also high. These findings highlight the urgent need for comprehensive strategies, including antibiotic stewardship and improved screening and treatment practices, to address the growing threat of antibiotic-resistant gonorrhea. International collaboration and ongoing surveillance are essential to monitor and mitigate the spread of resistant strains.Gonorrhea, a sexually transmitted infection caused by *Neisseria gonorrhoeae*, remains a significant public health concern in China. In 2022, China reported 96,313 cases of gonorrhea, making it the fourth most common notifiable infectious disease. The rise in antimicrobial-resistant strains, particularly ceftriaxone-resistant clones, poses a significant challenge to control efforts. The China Gonococcal Resistance Surveillance Program (China-GRSP) monitored 2,804 gonococcal isolates from 13 provinces, representing 4.1% of all reported cases. The prevalence of ceftriaxone resistance increased from 2.9% in 2017 to 8.1% in 2022, with five provinces reporting >10% resistance. Resistance to other antibiotics, such as ciprofloxacin (97.6%), penicillin (77.8%), tetracycline (77.1%), azithromycin (16.9%), and cefixime (16.0%), was also high. These findings highlight the urgent need for comprehensive strategies, including antibiotic stewardship and improved screening and treatment practices, to address the growing threat of antibiotic-resistant gonorrhea. International collaboration and ongoing surveillance are essential to monitor and mitigate the spread of resistant strains.