A multi-functional composite hydrogel (G-TSrP) was developed to enhance wound healing through immunomodulation and neovascularization. The hydrogel combines gelatin methacryloyl (GelMA) with tannic acid-strontium nanoparticles (TSrP), which are synthesized via a one-step mineralization process. TSrP nanoparticles release tannic acid (TA) and strontium ions (Sr²⁺), which promote macrophage polarization toward the M2 phenotype, facilitating tissue regeneration and angiogenesis. Despite TA's potential to inhibit angiogenesis, Sr²⁺ counteracts this effect, enhancing vascularization. The hydrogel supports wound closure under inflammation, promotes normal tissue formation, and induces neovascularization. In vivo studies confirmed the hydrogel's ability to modulate macrophage function and enhance tissue regeneration. The hydrogel's degradation coincides with host tissue ingrowth, and its composition allows for controlled release of TA and Sr²⁺, which regulate macrophage polarization and ECM remodeling. The hydrogel's biocompatibility and ability to modulate immune responses make it a promising candidate for wound healing applications. The study highlights the importance of balancing immune responses and angiogenesis in wound healing and demonstrates the potential of composite hydrogels in promoting tissue regeneration.A multi-functional composite hydrogel (G-TSrP) was developed to enhance wound healing through immunomodulation and neovascularization. The hydrogel combines gelatin methacryloyl (GelMA) with tannic acid-strontium nanoparticles (TSrP), which are synthesized via a one-step mineralization process. TSrP nanoparticles release tannic acid (TA) and strontium ions (Sr²⁺), which promote macrophage polarization toward the M2 phenotype, facilitating tissue regeneration and angiogenesis. Despite TA's potential to inhibit angiogenesis, Sr²⁺ counteracts this effect, enhancing vascularization. The hydrogel supports wound closure under inflammation, promotes normal tissue formation, and induces neovascularization. In vivo studies confirmed the hydrogel's ability to modulate macrophage function and enhance tissue regeneration. The hydrogel's degradation coincides with host tissue ingrowth, and its composition allows for controlled release of TA and Sr²⁺, which regulate macrophage polarization and ECM remodeling. The hydrogel's biocompatibility and ability to modulate immune responses make it a promising candidate for wound healing applications. The study highlights the importance of balancing immune responses and angiogenesis in wound healing and demonstrates the potential of composite hydrogels in promoting tissue regeneration.