The article reviews the mechanisms of cell death induced by taxanes, a class of drugs used in cancer chemotherapy. Taxanes, including paclitaxel, docetaxel, and cabazitaxel, primarily interfere with microtubule dynamics, leading to cell growth arrest and mitotic catastrophe. However, the precise mechanism of caspase activation and the detailed cell death pathway remain unclear. The authors suggest that taxanes may also induce micronucleation and irreversible nuclear membrane rupture, which could be a novel mechanism of action. They discuss the broader context of cell death mechanisms, including apoptosis, necroptosis, and other regulated and non-regulated processes, and highlight the challenges in cancer therapy due to the evolution of cancer cells to escape programmed cell death. The article emphasizes the importance of understanding these mechanisms to improve the efficacy of taxane-based treatments and overcome resistance.The article reviews the mechanisms of cell death induced by taxanes, a class of drugs used in cancer chemotherapy. Taxanes, including paclitaxel, docetaxel, and cabazitaxel, primarily interfere with microtubule dynamics, leading to cell growth arrest and mitotic catastrophe. However, the precise mechanism of caspase activation and the detailed cell death pathway remain unclear. The authors suggest that taxanes may also induce micronucleation and irreversible nuclear membrane rupture, which could be a novel mechanism of action. They discuss the broader context of cell death mechanisms, including apoptosis, necroptosis, and other regulated and non-regulated processes, and highlight the challenges in cancer therapy due to the evolution of cancer cells to escape programmed cell death. The article emphasizes the importance of understanding these mechanisms to improve the efficacy of taxane-based treatments and overcome resistance.