This article reviews the mechanisms of cell death in cancer chemotherapy using taxanes, such as paclitaxel, docetaxel, and cabazitaxel. Taxanes are microtubule-stabilizing agents that are effective in cancer treatment. They are generally thought to cause cell death by inducing mitotic arrest, mitotic catastrophe, and apoptosis. However, the precise mechanism by which taxanes trigger apoptosis is not fully understood. Recent studies suggest that taxanes may cause cell death through a newly recognized mechanism involving micronucleation and irreversible nuclear membrane rupture. This process occurs in both mitotic and non-mitotic cells and is not solely dependent on apoptosis. The article also discusses other cell death mechanisms, including apoptosis, necroptosis, and perforin-mediated cell death. It highlights the importance of understanding these mechanisms in developing more effective cancer therapies. The study emphasizes the role of nuclear envelope integrity in cancer cell death and the potential of targeting this process for improved treatment outcomes. The findings suggest that the nuclear membrane rupture caused by taxanes may be a key mechanism in their anti-cancer activity.This article reviews the mechanisms of cell death in cancer chemotherapy using taxanes, such as paclitaxel, docetaxel, and cabazitaxel. Taxanes are microtubule-stabilizing agents that are effective in cancer treatment. They are generally thought to cause cell death by inducing mitotic arrest, mitotic catastrophe, and apoptosis. However, the precise mechanism by which taxanes trigger apoptosis is not fully understood. Recent studies suggest that taxanes may cause cell death through a newly recognized mechanism involving micronucleation and irreversible nuclear membrane rupture. This process occurs in both mitotic and non-mitotic cells and is not solely dependent on apoptosis. The article also discusses other cell death mechanisms, including apoptosis, necroptosis, and perforin-mediated cell death. It highlights the importance of understanding these mechanisms in developing more effective cancer therapies. The study emphasizes the role of nuclear envelope integrity in cancer cell death and the potential of targeting this process for improved treatment outcomes. The findings suggest that the nuclear membrane rupture caused by taxanes may be a key mechanism in their anti-cancer activity.