This review discusses the role of cellular metabolism in cancer ferroptosis, a form of programmed cell death characterized by lipid peroxidation and membrane damage. The authors highlight the importance of glucose, fatty acid, amino acid, iron, and selenium metabolism in this process. They detail how disruptions in these metabolic pathways can lead to ferroptosis, and how targeting these pathways may offer new therapeutic strategies for cancer treatment. Key mechanisms include the regulation of redox balance, lipid peroxidation, and iron homeostasis. The review also explores the potential of ferroptosis inducers, such as FSP1 inhibitors, to enhance the effectiveness of cancer therapy by inducing ferroptosis in tumor cells.This review discusses the role of cellular metabolism in cancer ferroptosis, a form of programmed cell death characterized by lipid peroxidation and membrane damage. The authors highlight the importance of glucose, fatty acid, amino acid, iron, and selenium metabolism in this process. They detail how disruptions in these metabolic pathways can lead to ferroptosis, and how targeting these pathways may offer new therapeutic strategies for cancer treatment. Key mechanisms include the regulation of redox balance, lipid peroxidation, and iron homeostasis. The review also explores the potential of ferroptosis inducers, such as FSP1 inhibitors, to enhance the effectiveness of cancer therapy by inducing ferroptosis in tumor cells.