The article discusses the potential of using human induced pluripotent stem cells (iPSCs) and transdifferentiated cells to model human aging and age-related diseases. It highlights the limitations of using non-vertebrate and vertebrate models for studying aging and emphasizes the need for human-specific models. The authors explore the advantages and challenges of using iPSCs and transdifferentiated cells, including their ability to recapitulate the complexity of human aging and the potential for genetic manipulation. They review recent progress in this area, such as the use of iPSCs from patients with age-related diseases and premature aging syndromes to study aging mechanisms and drug screening. The article also discusses the use of 2D and 3D culture models, including tissue-engineered models and organoids, to study aging and age-related diseases. Finally, it outlines future directions for the field, including the development of multicellular age-equivalent models and the use of 3D bioprinting for creating artificial organs and tissues.The article discusses the potential of using human induced pluripotent stem cells (iPSCs) and transdifferentiated cells to model human aging and age-related diseases. It highlights the limitations of using non-vertebrate and vertebrate models for studying aging and emphasizes the need for human-specific models. The authors explore the advantages and challenges of using iPSCs and transdifferentiated cells, including their ability to recapitulate the complexity of human aging and the potential for genetic manipulation. They review recent progress in this area, such as the use of iPSCs from patients with age-related diseases and premature aging syndromes to study aging mechanisms and drug screening. The article also discusses the use of 2D and 3D culture models, including tissue-engineered models and organoids, to study aging and age-related diseases. Finally, it outlines future directions for the field, including the development of multicellular age-equivalent models and the use of 3D bioprinting for creating artificial organs and tissues.