This perspective discusses the use of human induced pluripotent stem cells (iPSCs) and transdifferentiated cells to model human aging in a dish, complementing animal models. The generation of human model systems is critical for understanding aging mechanisms and identifying interventions to extend health and lifespan. While non-vertebrate and vertebrate models have provided insights into aging-related proteins and pathways, they have limitations in recapitulating human complexity and biological variability. Human cell models, such as primary cells from young and old individuals or those with age-related diseases, offer a platform to study aging in a dish. However, their limited availability, accessibility, and in vitro expansion capacity pose challenges. iPSCs and transdifferentiated cells can provide valuable insights into aging processes and help identify anti-aging drugs. iPSCs from aging-associated diseases can reveal mechanisms governing aging, while transdifferentiated cells retain aging-associated features of the original cells. 2D and 3D models are used to study aging, with 3D models offering better recapitulation of physiological processes. Organoids, which are 3D multicellular cultures, provide near-physiological models for studying aging at the organ level. Despite their potential, organoids have limitations in recapitulating aging profiles and vascularization. The use of 3D models and organoids is expected to advance the understanding of aging and age-related diseases, with future directions including the development of multicellular age-equivalent models and the use of bioprinting technologies to create artificial organs. The integration of these models with genetic and pharmacological approaches will be crucial for unraveling the complexities of aging and developing effective interventions.This perspective discusses the use of human induced pluripotent stem cells (iPSCs) and transdifferentiated cells to model human aging in a dish, complementing animal models. The generation of human model systems is critical for understanding aging mechanisms and identifying interventions to extend health and lifespan. While non-vertebrate and vertebrate models have provided insights into aging-related proteins and pathways, they have limitations in recapitulating human complexity and biological variability. Human cell models, such as primary cells from young and old individuals or those with age-related diseases, offer a platform to study aging in a dish. However, their limited availability, accessibility, and in vitro expansion capacity pose challenges. iPSCs and transdifferentiated cells can provide valuable insights into aging processes and help identify anti-aging drugs. iPSCs from aging-associated diseases can reveal mechanisms governing aging, while transdifferentiated cells retain aging-associated features of the original cells. 2D and 3D models are used to study aging, with 3D models offering better recapitulation of physiological processes. Organoids, which are 3D multicellular cultures, provide near-physiological models for studying aging at the organ level. Despite their potential, organoids have limitations in recapitulating aging profiles and vascularization. The use of 3D models and organoids is expected to advance the understanding of aging and age-related diseases, with future directions including the development of multicellular age-equivalent models and the use of bioprinting technologies to create artificial organs. The integration of these models with genetic and pharmacological approaches will be crucial for unraveling the complexities of aging and developing effective interventions.