This scoping review examines the challenges, barriers, and facilitators of telemedicine implementation in India, focusing on individual, provider, and system levels. The review, conducted from January 2019 to January 2024, included 26 studies (14 quantitative, 8 qualitative, and 4 mixed-methods) from various regions in India. Key findings include: **Individual-Level Challenges and Barriers:** - Limited digital literacy, particularly among older adults and rural residents. - Health literacy issues. - Limited smartphone access and unreliable internet connectivity. - Socio-cultural preferences for in-person consultations. **Facilitators:** - Family involvement. - Training programs. - Community outreach. **Provider-Level Challenges and Barriers:** - Lack of training and familiarity with telehealth platforms. - Concerns about care quality. - Insufficient infrastructure. - Medico-legal and regulatory concerns. - Inadequate funding and resistance to change. **Facilitators:** - Ongoing training. - Clear guidelines. - User-friendly telehealth systems. **System-Level Challenges and Barriers:** - Integrating telemedicine into existing infrastructure. - Ensuring data security. - Inadequate funding. - Resistance to change. - Disparities in technology access between urban and rural areas. **Facilitators:** - Policy support. - Investment in infrastructure. - Collaborative efforts. - Standardized protocols. - Clear regulatory frameworks. The review highlights the need for strengthening digital infrastructure, enhancing digital literacy, standardizing protocols, and developing clear regulatory frameworks to support the successful implementation of telemedicine in India. Continuous research and public awareness campaigns are essential to ensure the sustainable and effective use of telemedicine services.This scoping review examines the challenges, barriers, and facilitators of telemedicine implementation in India, focusing on individual, provider, and system levels. The review, conducted from January 2019 to January 2024, included 26 studies (14 quantitative, 8 qualitative, and 4 mixed-methods) from various regions in India. Key findings include: **Individual-Level Challenges and Barriers:** - Limited digital literacy, particularly among older adults and rural residents. - Health literacy issues. - Limited smartphone access and unreliable internet connectivity. - Socio-cultural preferences for in-person consultations. **Facilitators:** - Family involvement. - Training programs. - Community outreach. **Provider-Level Challenges and Barriers:** - Lack of training and familiarity with telehealth platforms. - Concerns about care quality. - Insufficient infrastructure. - Medico-legal and regulatory concerns. - Inadequate funding and resistance to change. **Facilitators:** - Ongoing training. - Clear guidelines. - User-friendly telehealth systems. **System-Level Challenges and Barriers:** - Integrating telemedicine into existing infrastructure. - Ensuring data security. - Inadequate funding. - Resistance to change. - Disparities in technology access between urban and rural areas. **Facilitators:** - Policy support. - Investment in infrastructure. - Collaborative efforts. - Standardized protocols. - Clear regulatory frameworks. The review highlights the need for strengthening digital infrastructure, enhancing digital literacy, standardizing protocols, and developing clear regulatory frameworks to support the successful implementation of telemedicine in India. Continuous research and public awareness campaigns are essential to ensure the sustainable and effective use of telemedicine services.