The article discusses the progress in genomics over the past decade and outlines a vision for the future of genomic medicine. Since the completion of the Human Genome Project in 2003, genomics has become a key part of biomedical research. Advances in genomics have led to a better understanding of human biology and improved health outcomes, including new therapies for diseases like cancer. The National Human Genome Research Institute (NHGRI) has worked with the scientific community to define the key attributes of genomics and explore future directions. The vision for genomics is organized around five domains, from basic research to health applications, emphasizing the importance of understanding normal biology to improve health. The article also highlights the need for comprehensive genomic catalogues, new tools for genomics research, and the integration of genomic information with environmental and clinical data. It discusses the challenges of genomics research, including the need for new computational tools, the ethical implications of genomic data, and the importance of public participation. The article also addresses the role of genomics in understanding disease, the genetic and non-genetic bases of disease, and the potential of genomics to improve diagnostics and therapeutics. It emphasizes the need for education and training in genomics, as well as the importance of addressing ethical, legal, and social issues related to genomics. The article concludes with a call for continued research and collaboration to realize the full potential of genomics in improving human health.The article discusses the progress in genomics over the past decade and outlines a vision for the future of genomic medicine. Since the completion of the Human Genome Project in 2003, genomics has become a key part of biomedical research. Advances in genomics have led to a better understanding of human biology and improved health outcomes, including new therapies for diseases like cancer. The National Human Genome Research Institute (NHGRI) has worked with the scientific community to define the key attributes of genomics and explore future directions. The vision for genomics is organized around five domains, from basic research to health applications, emphasizing the importance of understanding normal biology to improve health. The article also highlights the need for comprehensive genomic catalogues, new tools for genomics research, and the integration of genomic information with environmental and clinical data. It discusses the challenges of genomics research, including the need for new computational tools, the ethical implications of genomic data, and the importance of public participation. The article also addresses the role of genomics in understanding disease, the genetic and non-genetic bases of disease, and the potential of genomics to improve diagnostics and therapeutics. It emphasizes the need for education and training in genomics, as well as the importance of addressing ethical, legal, and social issues related to genomics. The article concludes with a call for continued research and collaboration to realize the full potential of genomics in improving human health.