The article "Chemicals from lignin: an interplay of lignocellulose fractionation, depolymerisation, and upgrading" by W. Schutyser, T. Renders, S. Van den Bosch, G. T. Beckham, and B. F. Sels discusses the potential of lignin as a resource for chemical production in sustainable biorefineries. The authors highlight three key aspects: lignocellulose fractionation, lignin depolymerization, and upgrading towards targeted chemicals. They review the extensive research in these areas, ranging from established techniques to cutting-edge innovations, and provide comprehensive overviews of each aspect. The review emphasizes the importance of minimizing lignin condensation during fractionation and depolymerization, and the use of convergent transformations to simplify the raw product mixture. The article also introduces the authors' backgrounds and expertise, and provides an overview of lignocellulosic biomass composition and lignin chemistry, setting the stage for the subsequent discussion on the biorefinery process.The article "Chemicals from lignin: an interplay of lignocellulose fractionation, depolymerisation, and upgrading" by W. Schutyser, T. Renders, S. Van den Bosch, G. T. Beckham, and B. F. Sels discusses the potential of lignin as a resource for chemical production in sustainable biorefineries. The authors highlight three key aspects: lignocellulose fractionation, lignin depolymerization, and upgrading towards targeted chemicals. They review the extensive research in these areas, ranging from established techniques to cutting-edge innovations, and provide comprehensive overviews of each aspect. The review emphasizes the importance of minimizing lignin condensation during fractionation and depolymerization, and the use of convergent transformations to simplify the raw product mixture. The article also introduces the authors' backgrounds and expertise, and provides an overview of lignocellulosic biomass composition and lignin chemistry, setting the stage for the subsequent discussion on the biorefinery process.