The article provides a comprehensive overview of cancer incidence, mortality, and survival rates for children and adolescents in the United States, based on data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries. In 2014, an estimated 15,780 new cancer cases and 1,960 deaths from cancer were expected among children and adolescents aged birth to 19 years. The annual incidence rate is 186.6 per 1 million children. The most common cancers among children are acute lymphoblastic leukemia (ALL), brain and central nervous system (CNS) tumors, neuroblastoma, and non-Hodgkin lymphoma (NHL). Among adolescents, the most common cancers are Hodgkin lymphoma (HL), thyroid carcinoma, brain and CNS tumors, and testicular germ cell tumors. The article also discusses risk factors, symptoms, treatment, and long-term effects for common pediatric cancers, including leukemia, lymphoma, brain tumors, embryonal tumors, sarcomas, and gonadal germ cell tumors. It highlights the importance of early diagnosis and the need for continued surveillance and research to improve outcomes for children and adolescents with cancer.The article provides a comprehensive overview of cancer incidence, mortality, and survival rates for children and adolescents in the United States, based on data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries. In 2014, an estimated 15,780 new cancer cases and 1,960 deaths from cancer were expected among children and adolescents aged birth to 19 years. The annual incidence rate is 186.6 per 1 million children. The most common cancers among children are acute lymphoblastic leukemia (ALL), brain and central nervous system (CNS) tumors, neuroblastoma, and non-Hodgkin lymphoma (NHL). Among adolescents, the most common cancers are Hodgkin lymphoma (HL), thyroid carcinoma, brain and CNS tumors, and testicular germ cell tumors. The article also discusses risk factors, symptoms, treatment, and long-term effects for common pediatric cancers, including leukemia, lymphoma, brain tumors, embryonal tumors, sarcomas, and gonadal germ cell tumors. It highlights the importance of early diagnosis and the need for continued surveillance and research to improve outcomes for children and adolescents with cancer.