The article by Feringa, Huck, and Schoevaars discusses the design and application of chiroptical molecular switches, which are bistable organic molecules that can switch between two enantiomeric forms (P and M) through photochemical control. These switches are designed to meet practical requirements such as fatigue resistance, detectability, and non-destructive read-out. The authors focus on the use of sterically overcrowded unsymmetrical thioxanthenes to create helically shaped molecules that can reversibly interconvert between the P and M states. They demonstrate the potential of these switches in various applications, including optical recording systems, where the change in optical rotation at wavelengths remote from the switching wavelengths can be monitored. The article also explores the development of highly stereoselective optical molecular switching, gated response, and chiroptical switching between liquid crystalline phases. These advancements open up new possibilities for controlling chirality in materials and devices, with potential applications in information technology and other fields.The article by Feringa, Huck, and Schoevaars discusses the design and application of chiroptical molecular switches, which are bistable organic molecules that can switch between two enantiomeric forms (P and M) through photochemical control. These switches are designed to meet practical requirements such as fatigue resistance, detectability, and non-destructive read-out. The authors focus on the use of sterically overcrowded unsymmetrical thioxanthenes to create helically shaped molecules that can reversibly interconvert between the P and M states. They demonstrate the potential of these switches in various applications, including optical recording systems, where the change in optical rotation at wavelengths remote from the switching wavelengths can be monitored. The article also explores the development of highly stereoselective optical molecular switching, gated response, and chiroptical switching between liquid crystalline phases. These advancements open up new possibilities for controlling chirality in materials and devices, with potential applications in information technology and other fields.