The study provides global prevalence and incidence estimates for four curable sexually transmitted infections (STIs)—chlamydia, gonorrhoea, trichomoniasis, and syphilis—in women and men aged 15–49 years in 2016. For chlamydia, gonorrhoea, and trichomoniasis, 130 studies were eligible, while the Spectrum-STI database contained 978 data points for syphilis. The 2016 global prevalence estimates were: 3.8% for chlamydia in women, 2.7% in men; 0.9% for gonorrhoea in women, 0.7% in men; 5.3% for trichomoniasis in women, 0.6% in men; and 0.5% for syphilis in both genders. Incidence estimates totaled 376.4 million cases, including 127.2 million for chlamydia, 86.9 million for gonorrhoea, 156.0 million for trichomoniasis, and 6.3 million for syphilis. These estimates highlight the persistent global burden of these STIs, emphasizing the need for improved data collection and monitoring. The study underscores the importance of addressing these infections to meet global health targets, including the World Health Organization's strategy to reduce STI incidence by 2030. The findings indicate that these infections remain a significant public health challenge, with high prevalence in low- and middle-income countries. The study also notes that while the 2016 estimates are similar to those from 2012, they provide a baseline for tracking progress in combating STIs. The research highlights the need for better data integration with clinical care platforms and improved diagnostic testing methods to enhance surveillance and response efforts.The study provides global prevalence and incidence estimates for four curable sexually transmitted infections (STIs)—chlamydia, gonorrhoea, trichomoniasis, and syphilis—in women and men aged 15–49 years in 2016. For chlamydia, gonorrhoea, and trichomoniasis, 130 studies were eligible, while the Spectrum-STI database contained 978 data points for syphilis. The 2016 global prevalence estimates were: 3.8% for chlamydia in women, 2.7% in men; 0.9% for gonorrhoea in women, 0.7% in men; 5.3% for trichomoniasis in women, 0.6% in men; and 0.5% for syphilis in both genders. Incidence estimates totaled 376.4 million cases, including 127.2 million for chlamydia, 86.9 million for gonorrhoea, 156.0 million for trichomoniasis, and 6.3 million for syphilis. These estimates highlight the persistent global burden of these STIs, emphasizing the need for improved data collection and monitoring. The study underscores the importance of addressing these infections to meet global health targets, including the World Health Organization's strategy to reduce STI incidence by 2030. The findings indicate that these infections remain a significant public health challenge, with high prevalence in low- and middle-income countries. The study also notes that while the 2016 estimates are similar to those from 2012, they provide a baseline for tracking progress in combating STIs. The research highlights the need for better data integration with clinical care platforms and improved diagnostic testing methods to enhance surveillance and response efforts.