Chromatin Immunoprecipitation is a technique used to identify protein-DNA interactions in biological samples. The process involves treating the sample to form protein-chromatin crosslinks, shearing the sample to separate individual protein-DNA complexes, and then applying an antibody specific to a protein of interest to immunoprecipitate the complexes.Chromatin Immunoprecipitation is a technique used to identify protein-DNA interactions in biological samples. The process involves treating the sample to form protein-chromatin crosslinks, shearing the sample to separate individual protein-DNA complexes, and then applying an antibody specific to a protein of interest to immunoprecipitate the complexes.