A study published in Nature (2009) identifies over 1,600 highly conserved large non-coding RNAs (lincRNAs) in mammals using chromatin-state maps. These lincRNAs are found in intergenic regions and show strong evolutionary conservation, suggesting they are functionally significant. The research reveals that these lincRNAs are involved in diverse biological processes, including embryonic stem cell pluripotency, cell proliferation, and gene regulation. The study also demonstrates that lincRNAs are regulated by key transcription factors such as p53, NF-κB, Sox2, Oct4, and Nanog. The findings highlight the importance of lincRNAs in mammalian biology and provide a functional genomics framework for understanding their roles. The study addresses the challenge of identifying functional lincRNAs and inferring their putative functions through experimental validation. The results suggest that lincRNAs are an important component of the mammalian RNA world, with potential roles in transcriptional control and chromatin remodeling. The study also provides a method for identifying and characterizing lincRNAs, contributing to the understanding of non-coding RNA function in mammals.A study published in Nature (2009) identifies over 1,600 highly conserved large non-coding RNAs (lincRNAs) in mammals using chromatin-state maps. These lincRNAs are found in intergenic regions and show strong evolutionary conservation, suggesting they are functionally significant. The research reveals that these lincRNAs are involved in diverse biological processes, including embryonic stem cell pluripotency, cell proliferation, and gene regulation. The study also demonstrates that lincRNAs are regulated by key transcription factors such as p53, NF-κB, Sox2, Oct4, and Nanog. The findings highlight the importance of lincRNAs in mammalian biology and provide a functional genomics framework for understanding their roles. The study addresses the challenge of identifying functional lincRNAs and inferring their putative functions through experimental validation. The results suggest that lincRNAs are an important component of the mammalian RNA world, with potential roles in transcriptional control and chromatin remodeling. The study also provides a method for identifying and characterizing lincRNAs, contributing to the understanding of non-coding RNA function in mammals.