This review article explores the role of chronic inflammation and cytokines in carcinogenesis, focusing on two types of cancer associated with chronic inflammatory diseases: colitis-associated colorectal cancer (CAC) and cholangiocarcinoma (CCA). Chronic inflammation, which is often triggered by infections or chronic inflammatory conditions, can lead to malignant transformation of cells. Key cytokines such as TNF-α, IL-6, TGF-β, and IL-10 play crucial roles in various aspects of carcinogenesis, including the generation of reactive oxygen and nitrogen species (RONS), mutagenic effects, epithelial-mesenchymal transition (EMT), angiogenesis, and metastasis. The article discusses how these cytokines contribute to the development and progression of CAC and CCA, highlighting the importance of controlling the inflammatory process early in these diseases to reduce the risk of cancer. Additionally, it provides an in-depth analysis of the participation of these cytokines in CAC and CCA, emphasizing the complex interplay between inflammation, cytokines, and cancer development.This review article explores the role of chronic inflammation and cytokines in carcinogenesis, focusing on two types of cancer associated with chronic inflammatory diseases: colitis-associated colorectal cancer (CAC) and cholangiocarcinoma (CCA). Chronic inflammation, which is often triggered by infections or chronic inflammatory conditions, can lead to malignant transformation of cells. Key cytokines such as TNF-α, IL-6, TGF-β, and IL-10 play crucial roles in various aspects of carcinogenesis, including the generation of reactive oxygen and nitrogen species (RONS), mutagenic effects, epithelial-mesenchymal transition (EMT), angiogenesis, and metastasis. The article discusses how these cytokines contribute to the development and progression of CAC and CCA, highlighting the importance of controlling the inflammatory process early in these diseases to reduce the risk of cancer. Additionally, it provides an in-depth analysis of the participation of these cytokines in CAC and CCA, emphasizing the complex interplay between inflammation, cytokines, and cancer development.