This study investigates functional connectivity abnormalities in the cingulate and precuneus regions in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Using resting-state BOLD fMRI scans, researchers found that adults with ADHD showed decreased functional connectivity between the dorsal anterior cingulate cortex (dACC) and the precuneus and posterior cingulate cortex (PCC), which are components of the default-mode network. These findings suggest that the interaction between the dACC and the default-mode network may be a new locus of dysfunction in ADHD. The study also found that ADHD-related decreases in connectivity were observed between the precuneus and other components of the default-mode network, including the ventromedial prefrontal cortex and parts of the posterior cingulate cortex. These results, combined with prior evidence of volumetric abnormalities in the posterior regions of ADHD patients, suggest that the long-range connections between the dACC and the PCC and precuneus should be considered as a candidate locus of dysfunction in ADHD. The study highlights the importance of examining the neural substrates of ADHD-related behaviors, such as attentional lapses, and assessing the underlying circuits through analysis of temporal correlations among distributed brain regions. This method of functional connectivity provides detailed spatial maps of putatively functionally related regions. The findings suggest that the default-mode network activity is disrupted in ADHD, with decreased suppression of default-mode network activity in healthy adults predicted by decreased cue-related activation in prefrontal regions. The study also found that ADHD-related decreases in functional connectivity between the dACC and the default-mode network components were associated with symptoms of inattention and hyperactivity/impulsivity. The study concludes that the long-range connections between the dACC and the PCC and precuneus may represent a novel locus of dysfunction in ADHD, and that further research is needed to explore the potential neural basis for the link between working memory deficits and attentional fluctuations in ADHD.This study investigates functional connectivity abnormalities in the cingulate and precuneus regions in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Using resting-state BOLD fMRI scans, researchers found that adults with ADHD showed decreased functional connectivity between the dorsal anterior cingulate cortex (dACC) and the precuneus and posterior cingulate cortex (PCC), which are components of the default-mode network. These findings suggest that the interaction between the dACC and the default-mode network may be a new locus of dysfunction in ADHD. The study also found that ADHD-related decreases in connectivity were observed between the precuneus and other components of the default-mode network, including the ventromedial prefrontal cortex and parts of the posterior cingulate cortex. These results, combined with prior evidence of volumetric abnormalities in the posterior regions of ADHD patients, suggest that the long-range connections between the dACC and the PCC and precuneus should be considered as a candidate locus of dysfunction in ADHD. The study highlights the importance of examining the neural substrates of ADHD-related behaviors, such as attentional lapses, and assessing the underlying circuits through analysis of temporal correlations among distributed brain regions. This method of functional connectivity provides detailed spatial maps of putatively functionally related regions. The findings suggest that the default-mode network activity is disrupted in ADHD, with decreased suppression of default-mode network activity in healthy adults predicted by decreased cue-related activation in prefrontal regions. The study also found that ADHD-related decreases in functional connectivity between the dACC and the default-mode network components were associated with symptoms of inattention and hyperactivity/impulsivity. The study concludes that the long-range connections between the dACC and the PCC and precuneus may represent a novel locus of dysfunction in ADHD, and that further research is needed to explore the potential neural basis for the link between working memory deficits and attentional fluctuations in ADHD.