The article "CircRNAs: Pivotal Modulators of TGF-β Signalling in Cancer Pathogenesis" explores the intricate relationship between Circular RNAs (circRNAs) and the Transforming Growth Factor-β (TGF-β) signalling pathway in cancer. CircRNAs, initially considered byproducts of splicing errors, have emerged as sophisticated regulators of gene expression due to their unique circular structure and resistance to degradation. The study investigates the role of circRNAs in modulating TGF-β signalling, a key pathway involved in cancer progression and metastasis. Through comprehensive profiling and bioinformatics analyses, the authors reveal that specific circRNAs interact with TGF-β pathway components, influencing cellular processes such as epithelial-mesenchymal transition (EMT), migration, and cell proliferation. Additionally, circRNAs have shown promise as diagnostic and prognostic biomarkers, and their modulation of critical pathways like TGF-β signalling offers potential for cancer therapy. The review highlights the complex interplay between circRNAs and TGF-β, emphasizing their significance in cancer biology and clinical applications.The article "CircRNAs: Pivotal Modulators of TGF-β Signalling in Cancer Pathogenesis" explores the intricate relationship between Circular RNAs (circRNAs) and the Transforming Growth Factor-β (TGF-β) signalling pathway in cancer. CircRNAs, initially considered byproducts of splicing errors, have emerged as sophisticated regulators of gene expression due to their unique circular structure and resistance to degradation. The study investigates the role of circRNAs in modulating TGF-β signalling, a key pathway involved in cancer progression and metastasis. Through comprehensive profiling and bioinformatics analyses, the authors reveal that specific circRNAs interact with TGF-β pathway components, influencing cellular processes such as epithelial-mesenchymal transition (EMT), migration, and cell proliferation. Additionally, circRNAs have shown promise as diagnostic and prognostic biomarkers, and their modulation of critical pathways like TGF-β signalling offers potential for cancer therapy. The review highlights the complex interplay between circRNAs and TGF-β, emphasizing their significance in cancer biology and clinical applications.