Circadian Regulation of Bone Remodeling reviews the molecular mechanisms linking circadian rhythms to bone remodeling. Bone remodeling involves the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Studies show circadian fluctuations in bone turnover markers, such as collagen fragments and alkaline phosphatase, and circadian expression of genes involved in osteoblast and osteoclast functions. Serum levels of calcium, phosphate, parathyroid hormone, and calcitonin also exhibit circadian rhythms. However, establishing a direct link between circadian rhythms and bone remodeling in humans remains challenging due to difficulties in collecting bone samples and differences in circadian gene regulation between humans and mice. Despite these challenges, circadian regulation of bone remodeling could reveal novel mechanisms underlying bone disorders like osteoporosis. The review discusses the roles of osteoblasts, osteocytes, and osteoclasts in bone remodeling, their interactions, and the circadian regulation of gene expression. It also highlights the circadian rhythms of bone turnover markers and the phenotypic effects of Bmal1 knockout mice. The study emphasizes the need for further research using in vivo models to understand the circadian regulation of bone remodeling and its implications for bone health and disease.Circadian Regulation of Bone Remodeling reviews the molecular mechanisms linking circadian rhythms to bone remodeling. Bone remodeling involves the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Studies show circadian fluctuations in bone turnover markers, such as collagen fragments and alkaline phosphatase, and circadian expression of genes involved in osteoblast and osteoclast functions. Serum levels of calcium, phosphate, parathyroid hormone, and calcitonin also exhibit circadian rhythms. However, establishing a direct link between circadian rhythms and bone remodeling in humans remains challenging due to difficulties in collecting bone samples and differences in circadian gene regulation between humans and mice. Despite these challenges, circadian regulation of bone remodeling could reveal novel mechanisms underlying bone disorders like osteoporosis. The review discusses the roles of osteoblasts, osteocytes, and osteoclasts in bone remodeling, their interactions, and the circadian regulation of gene expression. It also highlights the circadian rhythms of bone turnover markers and the phenotypic effects of Bmal1 knockout mice. The study emphasizes the need for further research using in vivo models to understand the circadian regulation of bone remodeling and its implications for bone health and disease.