The article reviews the growing body of research linking circadian rhythm disruption to metabolic health issues, including obesity, metabolic syndrome, and type 2 diabetes. It highlights the complex biological mechanisms underlying these associations, focusing on the role of core clock genes (CCGs) such as CLOCK, BMAL1, PER, and CRY, and their regulation of circadian output genes (COGs). The authors discuss how circadian disruption can lead to altered expression of these genes, affecting cellular metabolism and contributing to adverse metabolic outcomes. The review also examines in vivo animal models and epidemiological studies to provide a comprehensive understanding of the mechanistic links between circadian disruption and metabolic health. Key findings include the importance of aligning food intake with circadian rhythms, the benefits of time-restricted feeding (TRF), and the potential of TRF as a therapeutic strategy for metabolic disorders. The article emphasizes the need for further research to expand the evidence base and refine the understanding of these relationships, with implications for the prevention and treatment of metabolic diseases.The article reviews the growing body of research linking circadian rhythm disruption to metabolic health issues, including obesity, metabolic syndrome, and type 2 diabetes. It highlights the complex biological mechanisms underlying these associations, focusing on the role of core clock genes (CCGs) such as CLOCK, BMAL1, PER, and CRY, and their regulation of circadian output genes (COGs). The authors discuss how circadian disruption can lead to altered expression of these genes, affecting cellular metabolism and contributing to adverse metabolic outcomes. The review also examines in vivo animal models and epidemiological studies to provide a comprehensive understanding of the mechanistic links between circadian disruption and metabolic health. Key findings include the importance of aligning food intake with circadian rhythms, the benefits of time-restricted feeding (TRF), and the potential of TRF as a therapeutic strategy for metabolic disorders. The article emphasizes the need for further research to expand the evidence base and refine the understanding of these relationships, with implications for the prevention and treatment of metabolic diseases.