This review paper focuses on the role of class III plant peroxidases (Prxs) in plant defense reactions against pathogens. Prxs are a large multigene family involved in various physiological processes, including lignification, suberization, and the synthesis of phytoalexins. They also participate in the metabolism of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which are crucial for plant defense. The paper discusses how Prxs are induced by pathogens and elicitors, and their involvement in the reinforcement of cell walls, production of antimicrobial metabolites, and the generation of ROS and RNS. The review highlights the complex signaling pathways that regulate Prx gene expression, including the roles of salicylic acid (SA), jasmonic acid (JA), and ethylene (ET). The integration of Prxs within the complex network of defense responses in plant cells is emphasized as a key area for future research.This review paper focuses on the role of class III plant peroxidases (Prxs) in plant defense reactions against pathogens. Prxs are a large multigene family involved in various physiological processes, including lignification, suberization, and the synthesis of phytoalexins. They also participate in the metabolism of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which are crucial for plant defense. The paper discusses how Prxs are induced by pathogens and elicitors, and their involvement in the reinforcement of cell walls, production of antimicrobial metabolites, and the generation of ROS and RNS. The review highlights the complex signaling pathways that regulate Prx gene expression, including the roles of salicylic acid (SA), jasmonic acid (JA), and ethylene (ET). The integration of Prxs within the complex network of defense responses in plant cells is emphasized as a key area for future research.